{"id":6533,"date":"2024-06-25T13:18:35","date_gmt":"2024-06-25T04:18:35","guid":{"rendered":"https:\/\/gistnews.co.kr\/?p=6533"},"modified":"2024-06-25T13:18:52","modified_gmt":"2024-06-25T04:18:52","slug":"6533","status":"publish","type":"post","link":"https:\/\/gistnews.co.kr\/?p=6533","title":{"rendered":"\uc0c8\ub85c\uc6b4 \ub098\ud2b8\ub968 \uac10\uc9c0 \uc2e0\uacbd, \ucd08\ud30c\ub9ac \uc7a5 \ub0b4\uc5d0\uc11c \ubc1c\uacac\ub418\ub2e4"},"content":{"rendered":"

 <\/p>\n

Postprandial sodium sensing by enteric neurons in Drosophila <\/i>– \uff62Nature Metabolism\uff63<\/p>\n

 <\/p>\n

GIST \uc0dd\uba85\uacfc\ud559\ubd80 \uae40\uc601\uc900 \uad50\uc218\ub97c \ud3ec\ud568\ud55c \uce74\uc774\uc2a4\ud2b8\u2022\ubbf8\uad6d UC San Diego \uacf5\ub3d9 \uc5f0\uad6c\ud300\uc774 \ucd08\ud30c\ub9ac \uc7a5\uc5d0\uc11c \ub098\ud2b8\ub968\uc744 \uac10\uc9c0\ud558\ub294 \uc0c8\ub85c\uc6b4 \uc7a5\uad00 \uc2e0\uacbd \uc138\ud3ec\ub97c \ubc1c\uacac\ud588\ub2e4. \ud574\ub2f9 \uc5f0\uad6c\ub294 \uc9c0\ub09c 4\uc6d4 3\uc77c \uad6d\uc81c \ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98 \uba54\ud0c0\ubcfc\ub9ac\uc998(Nature Metabolism)\u2019 \uc5d0 \uc2e4\ub838\ub2e4.<\/p>\n

 <\/p>\n

\"\"<\/p>\n

R10H08 R59H02 gene\uc774 GFP\ub85c \ud45c\uc9c0\ub41c INSO \uc2e0\uacbd \uc138\ud3ec\ub97c \ub2f4\uc740 \uacf5\ucd08\uc810 \ud604\ubbf8\uacbd \uc0ac\uc9c4\uc774\ub2e4.<\/p>\n

 <\/p>\n

\uc0c8\ub85c\uc6b4 \ub098\ud2b8\ub968 \uac10\uc9c0 \uc138\ud3ec<\/b>, <\/b>\ucd08\ud30c\ub9ac \uc7a5 \ub0b4\uc5d0\uc11c \ubc1d\ud788\ub2e4<\/b><\/p>\n

\ub098\ud2b8\ub968\uc740 \uc6b0\ub9ac \ubab8\uc758 \uc218\ubd84\ub7c9\uc744 \uc870\uc808\ud558\ub294 \uc911\uc694\ud55c \uc601\uc591\uc18c\ub2e4. \ub530\ub77c\uc11c \ub098\ud2b8\ub968 \ub18d\ub3c4 \uade0\ud615\uc740 \uadfc\uc218\ucd95, \uc138\ud3ec \uc0bc\ud22c\uc555 \uc870\uc808, \ud608\uc555 \uc870\uc808 \ub4f1 \uc6b0\ub9ac \ubab8\uacfc \uc138\ud3ec\ub97c \uac74\uac15\ud558\uac8c \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc544\uc8fc \uc911\uc694\ud558\ub2e4. \ub098\ud2b8\ub968\uc740 \uc774\uc628\ud654\ub3fc \ubb3c\uacfc \ubc18\uc751\uc131\uc774 \ud55c\uce35 \uc904\uc5b4\ub4e0 \uc18c\uae08\uc758 \ud615\ud0dc\ub85c \uc6b0\ub9ac \ubab8\uc5d0 \uc12d\ucde8\ub41c\ub2e4. \uc774\ub97c \uc704\ud574 \uad6c\uac15 \ub0b4 \ubbf8\uac01 \uc138\ud3ec\uc5d0\ub294 \uc18c\uae08\uc758 \uc591\uacfc \uc9e0\ub9db\uc744 \uce21\uc815\ud558\ub294 \ub098\ud2b8\ub968 \uc218\uc6a9\uccb4\uac00 \uc874\uc7ac\ud55c\ub2e4. \uc18c\uae08\uc5d0 \uc758\ud574 \uc218\uc6a9\uccb4\uac00 \ud65c\uc131\ud654\ub418\uba74 \uc138\ud3ec\ub294 \ub9d0\ucd08\uc5d0\uc11c \ub1cc\ub85c \ub4e4\uc5b4\uac00\ub294 \uc2e0\uacbd\uc744 \ud1b5\ud574 \ub1cc\uc5d0 \uc2e0\ud638\ub97c \uc804\ub2ec\ud55c\ub2e4.<\/p>\n

\ud558\uc9c0\ub9cc \uc785\uc5d0\uc11c \uc9e0\ub9db\uc744 \uac10\uc9c0\ud558\ub294 \ubbf8\uac01 \uc138\ud3ec \uc678\uc5d0 \ub2e4\ub978 \ub098\ud2b8\ub968 \uac10\uc9c0 \uc7a5\uce58\ub294 \uc6b0\ub9ac\uc758 \ubab8 \uc548\uc5d0 \uc788\uc744 \uac83\uc73c\ub85c \ucd94\uce21\ub9cc \ub410\uc744 \ubfd0, \uc2e4\uc81c\ub85c \ubc1c\uacac\ub41c \uc801\uc740 \uc5c6\uc5c8\ub2e4. \ub610\ud55c, \uc778\uac04\uc744 \ud3ec\ud568\ud55c \ud3ec\uc720\ub958\uc640 \ucd08\ud30c\ub9ac\uc758 \uc7a5 \uc2e0\uacbd\ub4e4(enteric neurons)\uc758 \uae30\ub2a5\uc5d0 \ub300\ud574\uc11c\ub294 \uac70\uc758 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc5c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \ucd08\ud30c\ub9ac\uc758 \uc704\uc7a5 \uc2e0\uacbd \uc911\uc5d0 \ub098\ud2b8\ub968\uc744 \uac10\uc9c0\ud558\ub294 \ub274\ub7f0\uc774 \uc874\uc7ac\ud568\uc744 \uc2e4\ud5d8\uc801\uc73c\ub85c \ubc1d\ud614\ub2e4.<\/p>\n

 <\/p>\n

\ub098\ud2b8\ub968 \uac10\uc9c0 \ub2a5\ub825\uc744 \uce21\uc815\ud558\ub294 \ud589\ub3d9 \uc2e4\ud5d8<\/b><\/p>\n

KAIST \uc0dd\uba85\uacfc\ud559\ubd80 \uc11c\uc131\ubc30 \uad50\uc218 \uc5f0\uad6c\ud300\uc740 \ucd08\ud30c\ub9ac\uc5d0\uc11c \uad6c\uac15(protosis) \ubbf8\uac01 \uc138\ud3ec \uc678\uc5d0 \uc18c\uae08\uc744 \uac10\uc9c0\ud558\ub294 \ub0b4\uc218\uc6a9\uccb4\uac00 \uc788\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \ubbf8\uac01 \uc138\ud3ec\uc758 \uae30\ub2a5\uc774 \uc81c\uac70\ub41c Ir76b \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc774\uc6a9\ud55c \uc2e4\ud5d8\uad70\uc744 \uc124\uc815\ud588\ub2e4. \uadf8\ub9ac\uace0 \ucd08\ud30c\ub9ac\uac00 \uc18c\uae08\uc744 \uc624\ub7ab\ub3d9\uc548 \uba39\uc9c0 \uc54a\uc73c\uba74 \uc18c\uae08\uc744 \ub354 \uc120\ud638\ud558\uac8c \ub41c\ub2e4\ub294 \uc544\uc774\ub514\uc5b4\uc5d0 \ucc29\uc548\ud574 \uc18c\uae08\uc774 \uc5c6\ub294 \ubc30\uc9c0\uc5d0 \ucd08\ud30c\ub9ac\ub97c 72\uc2dc\uac04 \ub3d9\uc548 \ub450\uc5c8\ub2e4. \uc774\ud6c4 \uc18c\uae08\uc774 \ub4e0 \uc124\ud0d5 \ubc30\uc9c0\uc640 \uc124\ud0d5\ub9cc \ub4e0 \ubc30\uc9c0\uac00 \uc788\ub294 \ud658\uacbd\uc5d0 \ucd08\ud30c\ub9ac\ub97c \ub450\ub2c8 \ucd08\ud30c\ub9ac\ub294 \ubbf8\uac01 \uc138\ud3ec \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud574 \uc9e0\ub9db\uc744 \ubabb \ub290\ub07c\ub294\ub370\ub3c4 \uc18c\uae08\uc774 \ub4e0 \ubc30\uc9c0\ub97c \ucc3e\uc544\uac00\ub294 \ud589\ub3d9\uc744 \ubcf4\uc600\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc5f0\uad6c\ud300\uc740 \ucd08\ud30c\ub9ac\uc758 \ubab8 \uc548 \uc5b4\ub518\uac00 \ubbf8\uac01 \uc138\ud3ec \uc678\uc5d0 \uc18c\uae08\uc744 \uac10\uc9c0\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc744 \uc9c0\ub2cc \uc138\ud3ec\uac00 \uc874\uc7ac\ud568\uc744 \uc54c\uc544\ub0c8\ub2e4. \ub098\uc544\uac00, \uac10\uc9c0 \uc0ac\uc2e4\uc774 \ub1cc\uc5d0 \uc804\ub2ec\ub3fc \uc18c\uae08\uc744 \ucc3e\ub294 \ud589\ub3d9\uc774 \uc77c\uc5b4\ub0ac\uc744 \uac83\uc774\ub77c \ucd94\uce21\ud588\ub2e4.<\/p>\n

 <\/p>\n

3<\/b>\uac1c \ud559\uad50 \uacf5\ub3d9\uc5f0\uad6c \ud504\ub85c\uc81d\ud2b8\ub97c \ud1b5\ud574 <\/b>INSO <\/b>\uc2e0\uacbd \uc138\ud3ec\ub97c \ubc1c\uacac\ud558\ub2e4<\/b><\/p>\n

GIST \uc0dd\uba85\uacfc\ud559\ubd80 \uae40\uc601\uc900 \uad50\uc218\ub294 \uad6d\ucc45 \uc5f0\uad6c\uc18c\uc778 \ud55c\uad6d \ucd08\ud30c\ub9ac \uc5f0\uad6c\uc790\uc6d0 \uc740\ud589(KDRC)\uc744 \uc6b4\uc601\ud558\uace0 \uc788\uc73c\uba70, KDRC\uac00 \ubcf4\uc720\ud558\uace0 \uc788\ub294 \ucd08\ud30c\ub9ac GAL4\ub77c\uc778\uc758 \uc7a5\uad00 \ubc1c\ud604 \uc591\uc0c1\uc744 \uc870\uc0ac\ud558\ub294 K-GUT \ud504\ub85c\uc81d\ud2b8\ub97c \uc11c\uc6b8\ub300\u2022\uce74\uc774\uc2a4\ud2b8\u2022\uc131\uade0\uad00\ub300 \uc5f0\uad6c\ud300\uacfc \uacf5\ub3d9\uc73c\ub85c \uc218\ud589\ud558\uace0 \uc788\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uae40 \uad50\uc218\ub294 \uc774\ubc88 \uc5f0\uad6c\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c INSO \ub274\ub7f0 \ud45c\uc9c0 \ubc29\ubc95\uc744 \uac1c\ubc1c\ud558\uac8c \ub41c \uac83\uc73c\ub85c \uc54c\ub824\uc84c\ub2e4.<\/p>\n

GIST \uc0dd\uba85\uacfc\ud559\ubd80\uac00 \uc6b4\uc601\ud558\ub294 KDRC\ub294 \uad6d\ub0b4 \ucd5c\ub300 \uaddc\ubaa8\uc758 \ucd08\ud30c\ub9ac \uc5f0\uad6c\uc790\uc6d0 \uc740\ud589\uc73c\ub85c, \ud558\uc6cc\ub4dc \ud734\uc988 \uc758\ud559\uc5f0\uad6c\uc18c\uc758 \uc790\ub12c\ub9ac\uc544 \uc5f0\uad6c \ucea0\ud37c\uc2a4\uc758 Fly Light Split-GAL4 Driver Collection\uc744 \ud3ec\ud568\ud55c \uc57d 1\ub9cc \uac1c\uc758 \ucd08\ud30c\ub9ac \uc885\ub4e4\uc744 \ub9e4\uc77c \uac74\uac15\ud558\uac8c \uc720\uc9c0\ud558\uace0 \uc788\ub2e4. \uac01 \uc885\ub4e4\uc740 \uc800\ub9c8\ub2e4 \ud2b9\uc815 \uc138\ud3ec\ub97c \ud2b9\uc815 \uc2dc\uae30\uc5d0 \ub9cc\ub4dc\ub294 GAL4 \uc720\uc804\uc790\ub97c \uc9c0\ub2c8\uace0 \uc788\ub294\ub370, \uc774\ub4e4\uc740 \uc774\ubc88 INSO \uc2e0\uacbd \uc138\ud3ec \ubc1c\uacac\uc5d0 \uacb0\uc815\uc801\uc73c\ub85c \uae30\uc5ec\ud55c Split GAL4 combination \uc2e4\ud5d8 \uc218\ud589\uc5d0 \uc808\ub300\uc801\uc73c\ub85c \ud544\uc694\ud588\ub358 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n

 <\/p>\n

Split GAL4 <\/b>\uc2dc\uc2a4\ud15c\uc73c\ub85c \uc7a5\uad00 <\/b>\uc138\ud3ec \ud2b9\uc774\uc801 \ud615\uc9c8 \uc804\ud658\uccb4 \uac1c\ubc1c\ud574<\/b><\/p>\n

\ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 Split GAL4 combination \uc2e4\ud5d8 \uae30\ubc95\uc744 \uc774\uc6a9\ud574 \uc18c\uae08 \uac10\uc9c0 \uc2e0\uacbd \uc138\ud3ec\uc778 INSO \uc2e0\uacbd\uc744 \ubc1c\uacac\ud588\ub2e4. \ud574\ub2f9 \uc2e4\ud5d8 \uae30\ubc95\uc740 \uc720\uc804\uc790 \ubc1c\ud604\uacfc \uae30\ub2a5\uc744 \uc54c\uc544\ubcfc \ub54c \ub9e4\uc6b0 \uc720\uc6a9\ud55c \uc5f0\uad6c \ubc29\ubc95\uc774\ub2e4. \uc774 \uc2e4\ud5d8\uc740 \uc804\uc0ac \uc778\uc790\ub97c \uc554\ud638\ud654\ud558\ub294 \ud6a8\ubaa8\uc758 GAL4 \uc720\uc804\uc790\ub97c \ube44\ub86f\ud574 \ud504\ub85c\ubaa8\ud130 \ubd80\ubd84(region)\uc758 \uc9e7\uc740 \uc11c\uc5f4\uc774\uba74\uc11c GAL4\uac00 \uacb0\ud569\ud558\ub294 \uc11c\uc5f4\uc778 UAS\ub85c \uad6c\uc131\ub41c\ub2e4.<\/p>\n

\uc2e4\ud5d8\uc758 \ud575\uc2ec \uc6d0\ub9ac\ub294 UAS \uc11c\uc5f4 \ub4a4\uc5d0 GFP\ub97c \uc5f0\uacb0\ud55c UAS \ucd08\ud30c\ub9ac\uc640 \ud504\ub85c\ubaa8\ud130 \ub4a4\uc5d0 GAL4 \uc720\uc804\uc790\ub97c \uc5f0\uacb0\ud55c GAL4 \uc6b4\ubc18(driver) \ucd08\ud30c\ub9ac\ub97c \uad50\ubc30(combination)\ud558\ub294 \uac83\uc774\ub2e4. \uad50\ubc30\ub85c \uc5bb\uc740 \uc790\uc190\ub4e4\uc740 \uc6d0\ud558\ub294 \uc720\uc804\uc790(target gene)\uac00 \ubc1c\ud604\ub41c \ud2b9\uc815 \uc138\ud3ec\ub9cc GFP\ub85c \ud45c\uc9c0\ub3fc \ud0dc\uc5b4\ub09c\ub2e4. \uc774\ud6c4 \ud615\ud615\uc0c9\uc0c9\uc758 GFP \ud56d\uccb4 \uc5fc\ub8cc(dye)\ub97c \ucc98\ub9ac\ud558\uba74 \ucd08\ud30c\ub9ac\uc758 \uadfc\uc721 \uc138\ud3ec, \uc2e0\uacbd \uc138\ud3ec, \ud575, \uc138\ud3ec \uace8\uaca9(cytoskeleton) \ub4f1\uc744 \uc2dc\uac01\uc801\uc73c\ub85c \ud45c\ud604\ud55c \ub370\uc774\ud130\ub97c \uc5bb\uc744 \uc218 \uc788\ub2e4.<\/p>\n

 <\/p>\n

\ud589\ub3d9 \uad00\ucc30<\/b>(Behavior Screen)<\/b>\uacfc \uc6d0\uc778 \uaddc\uba85<\/b>(casuality establishment)<\/b><\/p>\n

KAIST\u2022GIST \uacf5\ub3d9 \uc5f0\uad6c\ud300\uc740 \ucd08\ud30c\ub9ac\uc758 \uc2e0\uacbd \uc138\ud3ec\ub4e4\uc744 \ud558\ub098\uc529 \uc5b5\uc81c\ud55c \ub4a4 \uc18c\uae08 \uacb0\ud54d \uae30\uac04 \uc774\ud6c4\uc5d0 \ubc30\uc9c0 \uc120\ud0dd \uc2e4\ud5d8\uc5d0\uc11c \ucd08\ud30c\ub9ac\uac00 \uc18c\uae08 \ubc30\uc9c0\ub97c \ucc3e\uc544\uac00\ub294\uc9c0 \uc54c\uc544\ubcf4\ub294 \ud589\ub3d9 \uad00\ucc30\uc744 \uc9c4\ud589\ud588\ub2e4. \uadf8 \uacb0\uacfc \uc18c\uae08 \uacb0\ud54d \uae30\uac04 \uc774\ud6c4\uc5d0 \uc18c\uae08 \uc120\ud638 \ud604\uc0c1\uc774 \uc0ac\ub77c\uc9c0\ub294 \ucd08\ud30c\ub9ac\uc758 \uc720\uc804\uc790 \ub77c\uc778\uc774 \ubc1c\uacac\ub410\ub2e4. \uc774\ub4e4\uc740 \uc18c\uae08 \uacb0\ud54d \uae30\uac04 \uc774\ud6c4\uc5d0\ub3c4 \uc18c\uae08\uc5d0 \ub300\ud55c \uc120\ud638\ub3c4\uac00 \uac70\uc758 \ub610\ub294 \uc804\ud600 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

\uc6d0\uc778 \uaddc\uba85\uc744 \uc704\ud574 Split GAL4 combination \uc2e4\ud5d8\uc744 \uc218\ud589\ud55c \uacb0\uacfc, \uc5f0\uad6c\ud300\uc740 \ub0b4\ubd80 \uc7a5 \ub274\ub7f0(anterior enteric neurons) \uc720\uc804\uc790 \ubc1c\ud604\uc774 \uc5b5\uc81c\ub41c \ucd08\ud30c\ub9ac\ub4e4\uc774 \uc18c\uae08\uc5d0 \ub300\ud55c \uc120\ud638\ub3c4\ub97c \ub098\ud0c0\ub0b4\uc9c0 \uc54a\uc74c\uc744 \uc54c\uc544\ub0c8\ub2e4. \uc5f0\uad6c\ud300\uc740 \uadf8\uc911\uc5d0\uc11c\ub3c4 INSO \uc2e0\uacbd \uc138\ud3ec\uac00 \uc18c\uae08\uc744 \uac10\uc9c0\ud558\ub294 \uc138\ud3ec\uc774\uc790 \uc18c\uae08 \uacb0\ud54d \uae30\uac04 \uc774\ud6c4\uc5d0 \uc18c\uae08 \uc120\ud638\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0a4\ub294 \ub9e4\uac1c\uc790\uc784\uc744 \ubc1c\uacac\ud588\ub2e4.<\/p>\n

 <\/p>\n

\uc5f0\uad6c\uc758 \uc758\uc758\uc640 \ud55c\uacc4\uc810<\/b><\/p>\n

\ucd08\ud30c\ub9ac\uc640 \uc778\uac04\uc740 \ud544\uc218 \uc720\uc804\uc790\uc758 \uc57d 70%\ub97c \uacf5\uc720\ud558\uace0 \uc788\ub2e4. \ub530\ub77c\uc11c \uc18c\uae08 \uac10\uc9c0 \uba54\ucee4\ub2c8\uc998\uacfc \uad00\ub828\ub41c \ubd84\uc790\ub098 \uc720\uc804\uc790\ub97c \ucc3e\uc73c\uba74 \uc778\uac04\uc758 \ub0b4\uc218\uc6a9 \uac10\uac01\uc744 \uc5f0\uad6c\ud558\ub294\ub370 \ub3c4\uc6c0\uc774 \ub420 \uac00\ub2a5\uc131\uc774 \ub192\ub2e4. \uc5ec\ud0dc\uae4c\uc9c0\ub294 \ubab8 \uc678\ubd80 \ud658\uacbd\uc744 \uac10\uc9c0\ud558\ub294 \uc2e0\uacbd\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \ub9ce\uc558\ub2e4. \uadf8\ub7ec\ub098 \uc774\ubc88 \uc5f0\uad6c\uc640 \uac19\uc774 \ub0b4\uc218\uc6a9 \uac10\uac01\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc18c\uae08\uacfc \uac19\uc740 \uc778\uac04\uc5d0\uac8c \uc911\uc694\ud55c \uc601\uc591\uc18c\ub97c \uc5b4\ub5bb\uac8c \uac10\uc9c0\ud558\uace0 \ubc18\uc751\ud558\ub294\uc9c0\ub97c \ubc1d\ud600\ub0bc \uc218 \uc788\ub2e4. \uc774 \ubd84\uc57c\ub294 \uace0\ud608\uc555\uacfc \uac19\uc740 \uad00\ub828 \uc9c8\ubcd1 \uce58\ub8cc \uc57d\ubb3c \uac1c\ubc1c \ub4f1\uc5d0 \uc774\ubc14\uc9c0\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n

\ub367\ubd99\uc5ec \uae40\uc601\uc900 \uad50\uc218\ub294 INSO \uc2e0\uacbd \uc138\ud3ec \ub0b4 \ub098\ud2b8\ub968\uc744 \uac10\uc9c0\ud558\ub294 \ud2b9\uc815 \ubd84\uc790\ub294 \uc544\uc9c1 \ubc1d\ud600\ub0b4\uc9c0 \ubabb\ud588\ub2e4\uace0 \uc804\ud588\ub2e4. \ubbf8\uac01 \uc138\ud3ec\uc5d0\uc11c\ub294 Ir76b \uc218\uc6a9\uccb4\uac00 \uc18c\uae08\uc744 \uac10\uc9c0\ud558\ub294\ub370, INSO \uc2e0\uacbd \uc138\ud3ec\ub294 Ir76b \uc218\uc6a9\uccb4\uac00 \uc5c6\ub2e4. \uc774\uc5d0 \uae40 \uad50\uc218\ub294 INSO \uc2e0\uacbd \uc138\ud3ec\uac00 \uc5b4\ub5a4 \uae30\uc791\uc744 \ud1b5\ud574 \uc18c\uae08\uc744 \uc778\uc2dd\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \ud6c4\uc18d \uc5f0\uad6c\uc758 \ud544\uc694\uc131\uc744 \uc5b8\uae09\ud588\ub2e4.<\/p>\n

 <\/p>\n

\ud5a5\ud6c4 \uc5f0\uad6c<\/b>, <\/b>\uae40\uc601\uc900 \uad50\uc218\uc5d0\uac8c \ubb3b\ub2e4<\/b><\/p>\n

\uae40\uc601\uc900 \uad50\uc218\ub294 “\uc774\ubc88 \ub17c\ubb38\uc744 \ud1b5\ud574 \uc7a5\uad00 \uc2e0\uacbd\uc5d0 \uad00\uc2ec\uc774 \uc0dd\uacbc\uace0 \uc5ec\ub7ec \uac00\uc9c0 \uae30\ub2a5\uc744 \uc218\ud589\ud558\ub294 \uc7a5\uad00 \uc2e0\uacbd \uc138\ud3ec\ub97c \uc870\uc0ac\ud558\uace0 \uc788\ub2e4”\uace0 \ubc1d\ud614\ub2e4. \ud2b9\ud788 \ucd5c\uadfc\uc5d0\ub294 \uc7a5\uad00 \uc2e0\uacbd \uc138\ud3ec \uc911 \uc54c\ucf54\uc62c\uc5d0 \ubc18\uc751\ud558\ub294 \uc138\ud3ec\ub97c \ucc3e\uc558\uace0, \ub2e4\uc591\ud55c \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uacfc \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \uc2e0\uacbd \uc138\ud3ec\ub97c \ucc3e\ub294 \uc5f0\uad6c\ub97c \ud65c\ubc1c\ud788 \uc9c4\ud589\ud558\uace0 \uc788\ub2e4\uace0 \uc804\ud588\ub2e4. \ub354\ubd88\uc5b4 “\uc774\ubc88 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc774 \ubd84\uc57c\uc5d0 \ub300\ud574\uc11c \ubab0\ub790\ub358 \uac83\ub4e4\uc774 \ub9ce\uc558\uc74c\uc744 \uae68\ub2ec\uc558\uace0 \ub0b4\uc218\uc6a9 \uac10\uac01\uc5d0\ub3c4 \uad00\uc2ec\uc774 \uc0dd\uacbc\ub2e4”\uba70 \ubd84\uc790\uc720\uc804\ud559 \ub3d9\ubb3c \ubaa8\ub378\uc744 \ud65c\uc6a9\ud55c \ud5a5\ud6c4 \ud6c4\uc18d \uc5f0\uad6c\uc758 \uac00\ub2a5\uc131\uc5d0 \ub300\ud574\uc11c \uae0d\uc815\uc758 \uba54\uc2dc\uc9c0\ub97c \uc804\ud588\ub2e4.<\/p>\n

\ub9c8\uc9c0\ub9c9\uc73c\ub85c \uae40\uc601\uc900 \uad50\uc218\ub294 \uacfc\ud559 \uc5f0\uad6c\uc5d0\uc11c “\uc9c8\ubb38\uc744 \uc798 \uc124\uc815\ud558\ub294 \uac83\uacfc \uc0dd\ubb3c\ud559\uc801\uc778 \uae30\ubcf8 \uc6d0\ub9ac\ub97c \uc801\uc6a9\ud574 \uac04\ub2e8\ud558\uba74\uc11c\ub3c4 \ud6a8\uacfc\uc801\uc778 \uc2e4\ud5d8 \ubc29\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uac83\uc774 \uc911\uc694\ud558\ub2e4”\uace0 \ub9d0\ud588\ub2e4. \uc2e4\uc81c\ub85c \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \uc18c\uae08 \uc12d\ucde8\uac00 \ubd80\uc871\ud55c \ucd08\ud30c\ub9ac\ub294 \uc18c\uae08\uc5d0 \ub300\ud55c \uc120\ud638\ub3c4\uac00 \ub354\uc6b1 \uc99d\uac00\ud55c\ub2e4\ub294 \ud604\uc0c1\uc744 \ud65c\uc6a9\ud55c \uc2e4\ud5d8 \ubc29\ubc95 \uac1c\ubc1c\uc774 \uc911\uc694\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

KDRC \uc740\ud589\uc7a5\uc778 \uae40\uc601\uc900 \uad50\uc218\ub294 \uc9c0\ub09c 2~3\ub144\uc5d0 \uac78\uccd0 \ubcf4\uc720\ud558\uace0 \uc788\ub294 \ucd08\ud30c\ub9ac \uc885\ub4e4\uc758 \uc870\uc791 \uac00\ub2a5\ud55c \ud615\uc9c8\uc804\ud658 \uc138\ud3ec \ubd84\uc11d\uc744 \uc804\ubd80 \ub9c8\uccd0\ub454 \uc0c1\ud0dc\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uae40\uc601\uc900 \uad50\uc218 \uc5f0\uad6c\ud300\uc774 \ucd08\ud30c\ub9ac \uc790\uc6d0\uc744 \ud604\uba85\ud558\uac8c \ud65c\uc6a9\ud574\uc11c \ub0b4\uc218\uc6a9 \uac10\uac01 \uc2e0\uacbd \uc138\ud3ec\uc758 \uae30\ub2a5\uc744 \ucc3e\uc740 KDRC \ud504\ub85c\uc81d\ud2b8\uc758 \ucd08\uae30 \uc5f0\uad6c \uc131\uacfc \uc911 \ud558\ub098\ub2e4. \uae40\uc601\uc900 \uad50\uc218\ub294 \uacf5\ub3d9 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ub3d9\ubb3c \ub0b4\ubd80 \uc18c\uae08 \uac10\uc9c0 \uc2e0\uacbd \uc138\ud3ec \uc874\uc7ac\ub97c \ubc1d\ud788\uba70 \uc0dd\uba85\uacfc\ud559\uc758 \ub4dc\ub113\uc740 \uc138\uacc4\uc5d0 \ud55c \ubc1c\uc9dd \ub354 \ub2e4\uac00\uac14\ub2e4.<\/p>\n

 <\/p>\n

\uc774\uaddc\uc11c \uae30\uc790<\/p>\n

leegyuseo@gm.gist.ac.kr<\/u><\/a><\/p>\n

 <\/p>\n

\uff11 \uc2e0\uacbd \uc138\ud3ec(neuron): \uc2e0\uacbd\uacc4\ub97c \uad6c\uc131\ud558\ub294 \uc138\ud3ec\ub85c, \ub098\ud2b8\ub968\uacfc \uce7c\ub968\uacfc \uac19\uc740 \uc774\uc628 \ud1b5\ub85c\ub97c \ubc1c\ud604\ud574 \ub2e4\ub978 \uc138\ud3ec\uc640\ub294 \ub2ec\ub9ac \uc804\uae30\uc801\uc778 \ubc29\ubc95\uc73c\ub85c \uc2e0\ud638\ub97c \uc804\ub2ec\ud55c\ub2e4.
\n\uff12 INSO: Internal sodium-sensing\uc758 \uc57d\uc790.
\n\uff13 UAS(upstream activation sequence): \ud6a8\ubaa8\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \uc870\uc808 \uc5fc\uae30\uc11c\uc5f4\ub85c, \ud504\ub85c\ubaa8\ud130\uc640 \uad6c\ubcc4\ub3fc \uc778\uadfc \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc99d\uac00\uc2dc\ud0a8\ub2e4.
\n\uff14 GFP(Green Fluorescent protein, \ub179\uc0c9 \ud615\uad11 \ub2e8\ubc31\uc9c8): \uc790\uc678\uc120 \ubc94\uc704\uc758 \ube5b\uc5d0 \ub178\ucd9c\ub420 \ub54c \ub179\uc0c9 \ud615\uad11\uc744 \ub098\ud0c0\ub0b4\ub294 \ub2e8\ubc31\uc9c8\ub85c, \ud574\ud30c\ub9ac\uc5d0\uc11c \ucc98\uc74c \ucd94\ucd9c\ub410\ub2e4. GFP\ub294 \ubc1c\uacac \uc774\ud6c4 \ub3d9\ubb3c\uc774\ub098 \ub2e4\ub978 \uc885\uc5d0 \ub3c4\uc785\ub3fc
\n\uc720\uc804\uc790 \ubcc0\ud615 \uae30\uc220\uc5d0 \ud65c\ubc1c\ud788 \uc774\uc6a9\ub418\uace0 \uc788\ub2e4.
\n\uff15 \ub0b4\uc218\uc6a9 \uac10\uac01(interoception): \uc720\uae30\uccb4\uc5d0 \uc2e0\uccb4\uc758 \ub0b4\ubd80 \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud558\ub294 \uc758\uc2dd\uc801 \ubb34\uc758\uc2dd\uc801 \uac10\uac01\uc758 \ubaa8\uc74c\uc73c\ub85c, \uc2e0\uccb4\uc758 \uc0dd\ub9ac\uc801 \uc0c1\ud0dc\ub97c \uad00\ub9ac\ud558\ub294 \uae30\ub2a5\uc744 \ud55c\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

  Postprandial sodium sensing by enteric neurons in Drosophila – \uff62Nature Metabolism\uff63   GIST \uc0dd\uba85\uacfc\ud559\ubd80 \uae40\uc601\uc900 \uad50\uc218\ub97c \ud3ec\ud568\ud55c \uce74\uc774\uc2a4\ud2b8\u2022\ubbf8\uad6d UC San Diego \uacf5\ub3d9 \uc5f0\uad6c\ud300\uc774 \ucd08\ud30c\ub9ac \uc7a5\uc5d0\uc11c \ub098\ud2b8\ub968\uc744 \uac10\uc9c0\ud558\ub294 \uc0c8\ub85c\uc6b4 \uc7a5\uad00 \uc2e0\uacbd \uc138\ud3ec\ub97c \ubc1c\uacac\ud588\ub2e4. \ud574\ub2f9 \uc5f0\uad6c\ub294 \uc9c0\ub09c 4\uc6d4 3\uc77c \uad6d\uc81c \ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98 \uba54\ud0c0\ubcfc\ub9ac\uc998(Nature Metabolism)\u2019 \uc5d0 \uc2e4\ub838\ub2e4.   R10H08 R59H02 gene\uc774 GFP\ub85c \ud45c\uc9c0\ub41c INSO \uc2e0\uacbd \uc138\ud3ec\ub97c \ub2f4\uc740 […]<\/p>\n","protected":false},"author":159,"featured_media":6534,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_post_was_ever_published":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[248,81],"tags":[],"coauthors":[378],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/gistnews.co.kr\/wp-content\/uploads\/2024\/06\/\ud559\uc220-\uc0ac\uc9c4.png?fit=934%2C968&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/sdL9j0-6533","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/6533"}],"collection":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/users\/159"}],"replies":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6533"}],"version-history":[{"count":2,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/6533\/revisions"}],"predecessor-version":[{"id":6536,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/6533\/revisions\/6536"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/media\/6534"}],"wp:attachment":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6533"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcoauthors&post=6533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}