{"id":7037,"date":"2025-09-19T13:35:16","date_gmt":"2025-09-19T04:35:16","guid":{"rendered":"https:\/\/gistnews.co.kr\/?p=7037"},"modified":"2025-09-19T13:35:16","modified_gmt":"2025-09-19T04:35:16","slug":"gist-%ec%a0%84%ec%b0%bd%eb%8d%95-%ea%b5%90%ec%88%98-%ec%97%b0%ea%b5%ac%ed%8c%80-%eb%a9%b4%ec%97%ad%ec%84%b8%ed%8f%ac-%ed%99%9c%ec%84%b1%ed%99%94-%ea%b5%ac%ec%a1%b0-%eb%a9%94%ec%bb%a4%eb%8b%88","status":"publish","type":"post","link":"https:\/\/gistnews.co.kr\/?p=7037","title":{"rendered":"GIST \uc804\ucc3d\ub355 \uad50\uc218 \uc5f0\uad6c\ud300, \uba74\uc5ed\uc138\ud3ec \ud65c\uc131\ud654 \uad6c\uc870 \uba54\ucee4\ub2c8\uc998 \uaddc\uba85"},"content":{"rendered":"

 <\/p>\n

\"\"
\uc0ac\uc9c4 \uc81c\uacf5 = \uc5f0\uad6c\ud300<\/figcaption><\/figure>\n

\uc0dd\uba85\uacfc\ud559\uacfc \uc804\ucc3d\ub355 \uad50\uc218\uac00 \uc9c0\ub3c4\ud558\uace0 \uc11c\uc6d0\ucc3d \ubc15\uc0ac\uacfc\uc815\uc0dd\uc774 \uc218\ud589\ud55c \uc5f0\uad6c\uac00 \uad6d\uc81c\ud559\uc220\uc9c0 <PNAS>\uc5d0 \ubcf4\uace0\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ubbf8\uc138\uc735\ubaa8\uac00 \uba74\uc5ed\uc138\ud3ec\uc758 \ub2e4\uc591\ud55c \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600 \uc8fc\ubaa9\ubc1b\uc558\ub2e4.<\/p>\n

T\uc138\ud3ec \ubbf8\uc138\uc735\ubaa8 \ud615\uc131 \uc6d0\ub9ac \uaddc\uba85<\/strong><\/p>\n

GIST \uc804\ucc3d\ub355 \uad50\uc218\uc758 \uc5f0\uad6c\uc2e4\uc740 \uba74\uc5ed\uc138\ud3ec\uc758 \ud558\ub098\uc778 T\uc138\ud3ec\uc5d0 \uad00\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud55c\ub2e4. \ub610\ud55c T\uc138\ud3ec \ud45c\uba74\uc758 \ubbf8\uc138\uc735\ubaa8\uac00 \ub0b4\uc678\ubd80\uc758 \ud56d\uc6d0\uc744 \uc778\uc2dd\ud558\ub294 \ub370 \uc911\uc694\ud55c \uae30\ub2a5\uc744 \ud558\ub294 \uad6c\uc870\uccb4\ub77c\ub294 \uc0ac\uc2e4\uacfc \ud2b9\uc815 \ud658\uacbd\uc5d0\uc11c \ubc29\ucd9c\ub3fc \uc815\ubcf4\uc804\ub2ec\uccb4\ub85c\uc11c \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ucd5c\ucd08\ub85c \ubc1d\ud614\ub2e4. \uadf8\ub7ec\ub098 \uc5ec\uc804\ud788 \ubbf8\uc138\uc735\ubaa8\uac00 \uc5b4\ub5bb\uac8c \ud615\uc131\ub418\ub294\uc9c0 \ub610\ub294 T\uc138\ud3ec\ub85c\ubd80\ud130 \uc5b4\ub5bb\uac8c \ubc29\ucd9c\ub418\ub294\uc9c0\uc5d0 \uad00\ud55c \uc5f0\uad6c\ub294 \ub9ce\uc774 \uc9c4\ud589\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 T\uc138\ud3ec \ud45c\uba74\uc758 \ubbf8\uc138\uc735\ubaa8\ub97c \uc870\uc808\ud558\ub294 \uc778\uc790\ub97c \ucc3e\uc544 \ubc1c\uad74\ud558\uace0, \uc774\ub7ec\ud55c \uc778\uc790\uc5d0 \uc758\ud574 \ubbf8\uc138\uc735\ubaa8\uac00 \uba74\uc5ed\ubc18\uc751\uc5d0\uc11c \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud558\ub294\uc9c0\ub97c \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc9c4\uc740 T\uc138\ud3ec \ubc1c\ub2ec \uacfc\uc815\uc5d0\uc11c \uc774\uc911\uc74c\uc131\uc5d0\uc11c \uc774\uc911\uc591\uc131, \ub2e8\uc77c\uc591\uc131 \ub2e8\uacc4\ub85c \uc804\ud658\ud558\ub294 \uacfc\uc815 \uc911 \ubbf8\uc138\uc735\ubaa8\uc758 \ubc1c\ud604\uc774 \uc774\uc911\uc591\uc131 \ub2e8\uacc4\uc5d0\uc11c\ub9cc \uc5b5\uc81c\ub41c \uac83\uc744 \ud655\uc778\ud588\ub2e4. \ub610\ud55c \uc774 \uacfc\uc815\uc5d0\uc11c Cdc42 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc774 \uc5f0\uad00\ub410\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4. Cdc42 \uc720\uc804\uc790\ub294 \uc138\ud3ec\uac00 \ud2b9\uc815 \ubd80\uc704\ub85c \uc62e\uaca8\uac08 \ub54c \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \uad6c\uc870\uccb4\uc778 filopodia\uc758 \ud615\uc131\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc5f0\uad6c\uc9c4\uc740 T\uc138\ud3ec\uc758 \ubbf8\uc138\uc735\ubaa8\uac00 \uc77c\ubc18\uc801\uc778 \uc138\ud3ec\uc758 filopodia\uc640 \uc720\uc0ac\ud55c \ud2b9\uc131\uc744 \uac00\uc9c4\ub2e4\ub294 \uc0ac\uc2e4\uc5d0 \uc8fc\ubaa9\ud574 \ud574\ub2f9 \uc720\uc804\uc790\ub97c \ud1b5\ud574 \ubbf8\uc138\uc735\ubaa8 \ud615\uc131\uc758 \ubd84\uc790\uc801\uc778 \uae30\uc804\uc744 \ubc1d\ud600\ub0b4\uace0 \ubbf8\uc138\uc735\ubaa8\uc758 \uae30\ub2a5\uc801\uc778 \uc5f0\uad6c\ub97c \ub354 \uc124\ub4dd\ub825 \uc788\uac8c \uc8fc\uc7a5\ud588\ub2e4.<\/p>\n

\uc120\ud589 \uc5f0\uad6c\uc5d0\uc11c\ub294 T\uc138\ud3ec\uac00 \ud56d\uc6d0 \uc9c0\uc2dc \uc138\ud3ec\uc640 \uba74\uc5ed \uc2dc\ub0c5\uc2a4\ub97c \ud615\uc131\ud560 \ub54c \ubbf8\uc138\uc735\ubaa8 \uad6c\uc870\uac00 \ubd95\uad34\ud55c\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ubbf8\uc138\uc735\ubaa8\uc5d0 TCR \uc2e0\ud638\uc804\ub2ec \ubd84\uc790\uac00 \ubc00\uc9d1\ub3fc \uc788\uc5b4 \ud56d\uc6d0 \uc778\uc2dd \uacfc\uc815\uc5d0\uc11c \uc0c1\ub300 \uc138\ud3ec \ud45c\uba74\uc73c\ub85c, \ub3d9\uc801\uc73c\ub85c \uc774\ub3d9\ud558\ub294 \uac83\uc744 \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c \ud655\uc778\ud588\uae30 \ub54c\ubb38\uc5d0 \ubbf8\uc138\uc735\ubaa8 \uad6c\uc870\uac00 \ubd95\uad34\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \uc124\ub4dd\ub825\uc774 \uc5c6\ub2e4\uace0 \uc0dd\uac01\ud588\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c T\uc138\ud3ec\uc758 \uba74\uc5ed \uc2dc\ub0c5\uc2a4 \ud615\uc131 \uacfc\uc815\uc5d0\uc11c \ubbf8\uc138\uc735\ubaa8\ub294 \uc0ac\ub77c\uc9c0\ub294 \uac83\uc774 \uc544\ub2c8\ub77c TCR\uc774 \ubc00\uc9d1\ud55c \ubcf5\ud569\uccb4\uc778 TCR \ub9c8\uc774\ud06c\ub85c\ud074\ub7ec\uc2a4\ud130 \uc790\uccb4\ub780 \uac83\uc744 \uc8fc\uc7a5\ud558\uace0 \uc774\ub97c \uc99d\uba85\ud588\ub2e4.<\/p>\n

\uc815\uc801 \uc548\ud14c\ub098\uc5d0\uc11c \ub3d9\uc801 \uba74\uc5ed \ud50c\ub7ab\ud3fc\uc73c\ub85c<\/strong><\/p>\n

T\uc138\ud3ec \ubbf8\uc138\uc735\ubaa8\ub294 \uc190\uac00\ub77d\ucc98\ub7fc \ub3cc\ucd9c\ub41c \uad6c\uc870\ub85c T\uc138\ud3ec \uc218\uc6a9\uccb4(TCR)\uc640 \ubcf4\uc870 \uc790\uadf9 \ubd84\uc790\ub97c \ub05d\ub2e8\uc5d0 \uc9d1\uc911\uc2dc\ucf1c \ucd08\uae30 \ud56d\uc6d0 \uc778\uc2dd\uc744 \uadf9\ub300\ud654\ud55c\ub2e4. \uc774\ub294 T\uc138\ud3ec \ubc1c\ub2ec \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70 \ud65c\uc131\ud654\ub418\ub294 \uacfc\uc815\uc5d0\uc11c TCR \ub9c8\uc774\ud06c\ub85c\ud074\ub7ec\uc2a4\ud130 \ud615\uc131\uacfc c-SMAC \ud615\uc131\uc744 \ucd09\uc9c4\ud574 \uc548\uc815\uc801\uc778 \uba74\uc5ed\ud559\uc801 \uc2dc\ub0c5\uc2a4\ub97c \uad6c\ucd95\ud55c\ub2e4. \ubbf8\uc138\uc735\ubaa8\ub294 \u201cT\uc138\ud3ec \uba74\uc5ed\uc2dc\ub0c5\ud1a0\uc880(TIS)\u201d\ub77c\uace0 \uba85\uba85\ud55c \ubbf8\uc138\uc18c\ud3ec\uc758 \uae30\uc6d0\uc73c\ub85c T\uc138\ud3ec\uac00 APC\uc5d0 \uba74\uc5ed \uba54\uc2dc\uc9c0\ub97c \uc804\ub2ec\ud558\ub294 \uc8fc\uc694 \ub9e4\uac1c\uccb4 \uc784\ubb34\ub97c \uc218\ud589\ud55c\ub2e4. Cdc42\ub294 RhoGTPase \uacc4\uc5f4\uc758 \ud575\uc2ec \uc870\uc808\uc778\uc790\ub85c \ubbf8\uc138\uc735\ubaa8\uc758 \uc218\uc640 \uae38\uc774\ub97c \uc870\uc808\ud55c\ub2e4. Cdc42\uac00 \uacb0\uc190\ub418\uac70\ub098 \uc5b5\uc81c\ub418\uba74 T\uc138\ud3ec\uc758 \ubbf8\uc138\uc735\ubaa8 \ud615\uc131\uc774 \ud06c\uac8c \uc800\ud574\ub3fc \ud56d\uc6d0 \uc778\uc2dd, TCR \uc2e0\ud638\uc804\ub2ec, APC \uacb0\ud569 \ubc0f TIS \uc0dd\uc0b0\uc774 \ubaa8\ub450 \uac10\uc18c\ud55c\ub2e4.<\/p>\n

\uae30\uc874 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ubbf8\uc138\uc735\ubaa8\ub97c \ud56d\uc6d0 \uac10\uc9c0 \ud6c4 \uc0ac\ub77c\uc9c0\ub294 \uc815\uc801 \uc548\ud14c\ub098\ub85c \ubd24\uc9c0\ub9cc, \uc774\ubc88 \uc5f0\uad6c\ub294 \ubbf8\uc138\uc735\ubaa8\uac00 \ud65c\uc131\ud654 \uc774\ud6c4\uc5d0\ub3c4 \ub0a8\uc544 TCR \ub9c8\uc774\ud06c\ub85c\ud074\ub7ec\uc2a4\ud130\ub97c \ub2a5\ub3d9\uc801\uc73c\ub85c \uc6b4\ubc18\ud558\uace0 \uc870\uc9c1\ud654\ud558\uba70 \ubc29\ucd9c\ub418\uc5b4 T\uc138\ud3ec \uba74\uc5ed\uc2dc\ub0c5\ud1a0\uc880(TIS)\ub85c \ud0c8\ubc14\uafc8\ud55c\ub2e4\ub294 \uc0c8\ub85c\uc6b4 \uc2dc\uac01\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc989, \uc815\uc801 \uc548\ud14c\ub098\uc5d0\uc11c \ub3d9\uc801 \uba74\uc5ed \ud50c\ub7ab\ud3fc\uc73c\ub85c \uae30\uc874\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \uc804\ud658\ud588\ub2e4.<\/p>\n

Cdc42,<\/strong>\ubbf8\uc138\uc735\ubaa8 \ud615\uc131\uc758 \ud575\uc2ec \uc870\uc808\uc790\uc784\uc744 \uc785\uc99d<\/strong><\/p>\n

\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \uac00\uc7a5 \uc911\uc694\ud55c \ubc1c\uacac\uc740 Cdc42\uac00 T\uc138\ud3ec \ubbf8\uc138\uc735\ubaa8 \ud615\uc131\uc758 \ud575\uc2ec \uc870\uc808\uc790\ub77c\ub294 \uac83\uc774\ub2e4. \uc774\ub97c \ud1b5\ud574 \ubbf8\uc138\uc735\ubaa8\uac00 T\uc138\ud3ec\uc758 \ud65c\uc131\ud654, TIS\uc758 \ud615\uc131 \ub4f1 \ub2e4\uc591\ud55c \uacfc\uc815\uc5d0 \uc774\ubc14\uc9c0\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600\ub0c8\ub2e4. \ub610\ud55c T\uc138\ud3ec\uac00 \ud749\uc120\uc5d0\uc11c \ubc1c\ub2ec\ud558\ub294 \uacfc\uc815\uc5d0\uc11c \ubbf8\uc138\uc735\ubaa8\uac00 \uc5b4\ub5bb\uac8c \ud615\uc131\ub418\uace0 \uc0ac\ub77c\uc9c0\ub294\uc9c0\uc5d0 \uad00\ud55c \uac83\ub3c4 \ubc1d\ud600\ub0c8\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc0ac\uc6a9\ud55c \uc2e4\ud5d8 \ubc29\ubc95 \uc911\uc5d0\uc11c \uc774\uc911 \uac80\uc99d \uc2dc\uc2a4\ud15c\uc744 \uac00\uc7a5 \uac15\uc870\ud558\uace0 \uc2f6\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc774 \ubc29\ubc95\uc740 Cdc42 \uc870\uac74\ubd80 \uacb0\uc190 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uacfc CASIN \uc5b5\uc81c\uc81c\ub97c \ubcd1\ud589\uc73c\ub85c \uc0ac\uc6a9\ud55c \uac83\uc774 \ud575\uc2ec\uc774\ub2e4. \uc870\uac74\ubd80 \uacb0\uc190 \ub9c8\uc6b0\uc2a4\uc758 \uacbd\uc6b0\uc5d0\ub294 TCR \ubcf5\ud569\uccb4 \uc790\uccb4\uc758 \ubc1c\ud604 \uc800\ud558, \ubc1c\ub2ec \uc774\uc0c1 \ubc0f \ub2e4\uc591\ud55c \ubcf4\uc0c1\uc801 \ubc18\uc751\uc73c\ub85c \ub2e4\uc591\ud55c \uc561\ud2f4 \uad00\ub828 \uc870\uc808 \uc720\uc804\uc790\ub4e4\uc758 \ubcc0\ud654\uac00 \uc2ec\ud574\uc11c, \ubbf8\uc138\uc735\ubaa8\uc758 \uae30\ub2a5\uc744 \uc774\uc57c\uae30\ud558\uae30\uc5d0 \uace0\ub824\ud574\uc57c \ud560 \ub2e4\uc591\ud55c \ubcc0\uc218\ub4e4\uc774 \uc874\uc7ac\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 Cdc42\uc5d0 \ud2b9\uc774\uc801\uc778 CASIN \uc5b5\uc81c\uc81c\ub97c T\uc138\ud3ec\uc5d0 \ucc98\ub9ac\ud574 \uacb0\uc190 \ubaa8\ub378\uc5d0\uc11c \ubc1c\uc0dd\ud558\ub294 \ub2e4\uc591\ud55c \ubcc0\uc218\ub97c \ubcf4\uc644\ud588\ub2e4. \ucd94\uac00\ub85c \uc5f0\uad6c\uc9c4\uc740 \uc2e4\ud5d8 \uacfc\uc815\uc5d0\uc11c \uacb0\uc190 \ub9c8\uc6b0\uc2a4\uac00 \ud0dc\uc5b4\ub098\uc9c0 \uc54a\uac70\ub098 \uc6d0\ud558\ub294 \ub9c8\uc6b0\uc2a4 \ub77c\uc778\uc774 \ud615\uc131\ub418\uc9c0 \uc54a\ub294 \uac83\uc774 \uac00\uc7a5 \uc5b4\ub824\uc6b4 \uc810\uc774\uc5c8\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ub9c8\uc6b0\uc2a4 \uad00\ub9ac\uac00 \ubbf8\ud761\ud558\uba74 \uc6d0\ud558\ub294 \ub9c8\uc6b0\uc2a4 \ub77c\uc778\uc744 \uc5bb\uc9c0 \ubabb\ud558\uace0 \uc218\ucc9c\ub9cc \uc6d0\ub300\uc758 \uc5f0\uad6c \uc190\uc2e4\uc774 \uc0dd\uae34\ub2e4\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ud55c \uc720\uc804\uc801 \uacb0\uc190(Knockout) \uc811\uadfc\uc5d0\uc11c\ub294 \ud574\ub2f9 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc774\uc911\uc591\uc131 \ubc1c\ub2ec \uacfc\uc815 \ubc0f \ub2e8\uc77c\uc591\uc131 \ubc1c\ub2ec \uacfc\uc815\uc5d0\uc11c \uc120\ud0dd\uc801\uc73c\ub85c \ucc28\ub2e8\ud588\ub2e4. \uadf8\ub9ac\uace0 \ubbf8\uc138\uc735\ubaa8 \ubc1c\ud604 \uc5b5\uc81c\uc640 \ud568\uaed8 \uc774\uc911\uc591\uc131\uc5d0\uc11c \ub2e8\uc77c\uc591\uc131 \uc138\ud3ec\ub85c \ubc1c\ub2ec\ud558\ub294 \uacfc\uc815 \uc911\uc5d0 \ubbf8\uc138\uc735\ubaa8\uc758 \ubc1c\ud604\uc774 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600\ub0c8\ub2e4. \ud558\uc9c0\ub9cc \ud2b9\uc815 \uc720\uc804\uc790 \uacb0\uc190\uc73c\ub85c \uc778\ud574 \ub2e4\uc591\ud55c \uc561\ud2f4 \uad00\ub828 \uc870\uc808 \uc778\uc790\ub4e4\uc758 \ubc1c\ud604\uc774 \uc99d\uac00\ud588\uace0, \ubc1c\ub2ec\uc774 \uc815\uc0c1\uc801\uc73c\ub85c \uc774\ub904\uc9c0\uc9c0 \uc54a\uc544 \ub9c8\uc6b0\uc2a4 \uccb4\ub0b4\uc5d0 \ubc1c\ub2ec\uc774 \ub05d\ub09c T\uc138\ud3ec\uac00 \uc874\uc7ac\ud558\uc9c0 \uc54a\ub294 \ubb38\uc81c\uac00 \ubc1c\uc0dd\ud588\ub2e4. \ub610\ud55c TCR \ubcf5\ud569\uccb4\uc758 \ubc1c\ud604\uc774 \uc904\uc5b4\ub4e4\uc5b4 \ub2e8\uc21c\ud788 \ubbf8\uc138\uc735\ubaa8\uc758 \uacb0\ud54d\uc73c\ub85c T\uc138\ud3ec\uc5d0 \uae30\ub2a5\uc801\uc778 \ubb38\uc81c\uac00 \ubc1c\uc0dd\ud55c \uac83\uc774 \uc544\ub2c8\ub77c\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub97c \ubcf4\uc644\ud558\uae30 \uc704\ud574 Cdc42\ub97c \ud2b9\uc774\uc801\uc73c\ub85c \uc800\ud574\ud558\ub294 CASIN \uc5b5\uc81c\uc81c\ub97c \ud65c\uc6a9\ud588\uace0, \ud574\ub2f9 \uc57d\ubb3c \ucc98\ub9ac \ud6c4\uc5d0 \ubb38\uc81c\ub97c \ud574\uacb0\ud588\ub2e4. \uacb0\uacfc\uc801\uc73c\ub85c Cdc42\uac00 \ubbf8\uc138\uc735\ubaa8 \ud615\uc131\uc744 \uc870\uc808\ud558\uace0, \uc774\ub97c \ud1b5\ud574 T\uc138\ud3ec \ubc1c\ub2ec\uacfc \uae30\ub2a5\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uacb0\ub860\uc744 \ub3c4\ucd9c\ud588\ub2e4.<\/p>\n

T\uc138\ud3ec \ubbf8\uc138\uc735\ubaa8, <\/strong>
\n\uba74\uc5ed\uce58\ub8cc \ud50c\ub7ab\ud3fc\uc73c\ub85c \ud655\uc7a5<\/strong><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 T\uc138\ud3ec\uac00 \ud65c\uc131\ud654\ub420 \ub54c \ub5a8\uc5b4\uc838 \ub098\uc624\ub294 \ubbf8\uc138\uc735\ubaa8\uac00 \ud56d\uc6d0 \uc81c\uc2dc \uc138\ud3ec\uc5d0 \uc804\ub2ec\ub410\uc744 \ub54c \ub2e4\uc591\ud55c \uba54\uc2dc\uc9c0\ub97c \uc804\ub2ec\ud560 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud614\ub2e4. \uc774\ub97c \uba74\uc5ed\uc2dc\ub0c5\ud1a0\uc880(TIS)\ub77c\uace0 \uba85\uba85\ud588\uace0, \uba74\uc5ed \uce58\ub8cc\uc81c\ub85c \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ubc88 \uc5f0\uad6c\ub294 \ud574\ub2f9 \uba74\uc5ed \uce58\ub8cc\uc81c\uc758 \uae30\uc6d0\uc774 T\uc138\ud3ec\uc758 \ubbf8\uc138\uc735\ubaa8\uc784\uc744 \uac15\ud654\ud558\ub294 \uc5f0\uad6c\uc774\uace0, \ubbf8\uc138\uc735\ubaa8\uc758 \ubc1c\ud604 \uc870\uc808\uc744 \ud1b5\ud574 \ub354 \ub192\uc740 \uc218\uc728\uc758 TIS \ubd84\ub9ac\uc5d0\ub3c4 \uc751\uc6a9\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\ud604\uc7ac \uc5f0\uad6c\uc9c4\uc740 TIS\ub97c \ud65c\uc6a9\ud55c \ud56d\uc554\ud6a8\uacfc \uad00\ub828 \uc5f0\uad6c\ub97c \ud65c\ubc1c\ud788 \uc9c4\ud589 \uc911\uc774\uace0, \uc870\ub9cc\uac04 \uc554 \uce58\ub8cc\uc758 \ud45c\uc900\uc744 \ubc14\uafc0 \uc218 \uc788\ub294 \ub180\ub784\ub9cc\ud55c \uc5f0\uad6c \uc131\uacfc \ubc1c\ud45c\ub97c \uc900\ube44\ud558\uace0 \uc788\ub2e4. \uc774\ud6c4 TIS\uc5d0 \uc6d0\ud558\ub294 \uc778\uc790\ub97c \ud0d1\uc7ac\ud574 \ub2e4\uc591\ud55c \uba74\uc5ed\uc9c8\ud658\uc5d0 \uc801\uc6a9\ud558\ub294 \uc2dc\ub3c4\ub97c \ud560 \uc608\uc815\uc774\uace0, \ucd5c\uc885\uc801\uc73c\ub85c TIS\uac00 \uae30\uc874 \uba74\uc5ed \uce58\ub8cc\uc81c\uc758 \ud6a8\uacfc\ub97c \ub6f0\uc5b4\ub118\uc740 \uce58\ub8cc\uc81c\ub85c \uc804 \uc138\uacc4 \ub2e4\uc591\ud55c \uba74\uc5ed\uc9c8\ud658\uc744 \uadf9\ubcf5\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\ub294 \ud558\ub098\uc758 \ud50c\ub7ab\ud3fc\uc73c\ub85c \uc790\ub9ac \uc7a1\uac8c \ud560 \uac83\uc774\ub77c\ub294 \ud3ec\ubd80\ub97c \ubc1d\ud614\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc5f0\uad6c\ud300\uc774 \uae30\uc874\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \ub4a4\uc9d1\ub294 \ub3c5\ubcf4\uc801\uc778 \uc131\uacfc\ub97c \ub0b4\uace0 \uc788\ub2e4\ub294 \uc790\ubd80\uc2ec\uc774 \ud06c\ub2e4\uace0 \ubc1d\ud788\uba70, \ucd08\uae30\uc5d0\ub294 \uc27d\uac8c \ubc1b\uc544\ub4e4\uc5ec\uc9c0\uc9c0 \uc54a\uc558\uc73c\ub098 \uc2dc\uac04\uc774 \ud750\ub974\uba70 \uc804 \uc138\uacc4 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc5f0\uad6c\ud300\uc758 \uacb0\uacfc\ub97c \uc778\uc6a9\ud558\uae30 \uc2dc\uc791\ud558\ub294 \ubaa8\uc2b5\uc744 \ubcf4\uba70 \ubcf4\ub78c\uc744 \ub290\ub080\ub2e4\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\uc0dd\uba85\uacfc\ud559\uacfc \uc804\ucc3d\ub355 \uad50\uc218\ub294 \u201c\uc5f0\uad6c \uacfc\uc815\uc740 \uc990\uac70\uc6b8 \ub54c\ubcf4\ub2e4 \ud798\ub4e4 \ub54c\uac00 \ub354 \ub9ce\uc9c0\ub9cc, \uadf8 \uacfc\uc815\uc744 \uadf9\ubcf5\ud574 \ub098\uac00\uba70 \uacb0\uc2e4\uc744 \ubd24\uc744 \ub54c \ub290\ub07c\ub294 \uac10\uc815\uc740 \uc5b4\ub5a4 \uc131\ucde8\uac10\ubcf4\ub2e4\ub3c4 \uc9dc\ub9bf\ud558\ub2e4. \ubcf8\uc778\uc758 \uc5f0\uad6c\ub97c \uc0ac\ub791\ud558\uace0, \uc790\uae30\uad00\ub9ac\ub97c \ud574\uac00\uba70 \ud798\ub4e0 \uacfc\uc815\uc744 \ud604\uba85\ud558\uac8c \uadf9\ubcf5\ud55c\ub2e4\uba74 \uc88b\uc740 \uc5f0\uad6c\uc790\uac00 \ub420 \uc218 \uc788\uc744 \uac83\uc774\ub2e4. \uc0dd\uba85\ud604\uc0c1\uc740 \ubc14\ub77c\ubcf4\ub294 \uc2dc\uac01\uc5d0 \ub530\ub77c \ub2e4\uc591\ud55c \ubc29\ud5a5\uc73c\ub85c \ud574\uc11d\ub420 \uc218 \uc788\uc5b4\uc11c \uc815\ub2f5\ub3c4, \uc624\ub2f5\ub3c4 \uc874\uc7ac\ud558\uc9c0 \uc54a\ub294\ub2e4\uace0 \uc0dd\uac01\ud55c\ub2e4. \uae30\uc874\uc758 \uc5f0\uad6c \uacb0\uacfc\ub4e4\uc744 \ub9f9\ubaa9\uc801\uc73c\ub85c \ubbff\uae30\ubcf4\ub2e4 \ub17c\ub9ac\uc801\uc778 \uc0ac\uace0\uc5d0 \uae30\ubc18\ud574 \ub2e4\uc591\ud55c \uc2dc\uac01\uc73c\ub85c \ubc14\ub77c\ubcf4\uba70 \ubcf8\uc778\uc758 \uc5f0\uad6c\uc5d0 \uc801\uc6a9\ud558\ub824\ub294 \ub178\ub825\uc744 \ud1b5\ud574 \ucc3d\uc758\uc801\uc778 \uc0ac\uace0\ub97c \uae30\ub974\uba74 \uc88b\uaca0\ub2e4.\u201d\ub77c\uace0 \uc804\ud588\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

  \uc0dd\uba85\uacfc\ud559\uacfc \uc804\ucc3d\ub355 \uad50\uc218\uac00 \uc9c0\ub3c4\ud558\uace0 \uc11c\uc6d0\ucc3d \ubc15\uc0ac\uacfc\uc815\uc0dd\uc774 \uc218\ud589\ud55c \uc5f0\uad6c\uac00 \uad6d\uc81c\ud559\uc220\uc9c0 <PNAS>\uc5d0 \ubcf4\uace0\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ubbf8\uc138\uc735\ubaa8\uac00 \uba74\uc5ed\uc138\ud3ec\uc758 \ub2e4\uc591\ud55c \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600 \uc8fc\ubaa9\ubc1b\uc558\ub2e4. T\uc138\ud3ec \ubbf8\uc138\uc735\ubaa8 \ud615\uc131 \uc6d0\ub9ac \uaddc\uba85 GIST \uc804\ucc3d\ub355 \uad50\uc218\uc758 \uc5f0\uad6c\uc2e4\uc740 \uba74\uc5ed\uc138\ud3ec\uc758 \ud558\ub098\uc778 T\uc138\ud3ec\uc5d0 \uad00\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud55c\ub2e4. \ub610\ud55c T\uc138\ud3ec \ud45c\uba74\uc758 \ubbf8\uc138\uc735\ubaa8\uac00 \ub0b4\uc678\ubd80\uc758 \ud56d\uc6d0\uc744 \uc778\uc2dd\ud558\ub294 \ub370 \uc911\uc694\ud55c \uae30\ub2a5\uc744 \ud558\ub294 \uad6c\uc870\uccb4\ub77c\ub294 \uc0ac\uc2e4\uacfc \ud2b9\uc815 \ud658\uacbd\uc5d0\uc11c \ubc29\ucd9c\ub3fc \uc815\ubcf4\uc804\ub2ec\uccb4\ub85c\uc11c […]<\/p>\n","protected":false},"author":173,"featured_media":7038,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_post_was_ever_published":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[32,248,81],"tags":[],"coauthors":[393],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/gistnews.co.kr\/wp-content\/uploads\/2025\/09\/image01.png?fit=925%2C364&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pdL9j0-1Pv","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7037"}],"collection":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/users\/173"}],"replies":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7037"}],"version-history":[{"count":1,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7037\/revisions"}],"predecessor-version":[{"id":7039,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7037\/revisions\/7039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/media\/7038"}],"wp:attachment":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7037"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcoauthors&post=7037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}