{"id":7331,"date":"2026-03-13T14:28:17","date_gmt":"2026-03-13T05:28:17","guid":{"rendered":"https:\/\/gistnews.co.kr\/?p=7331"},"modified":"2026-03-13T14:28:17","modified_gmt":"2026-03-13T05:28:17","slug":"%ea%b9%80%ec%9a%a9%ec%b2%a0%c2%b7%eb%b0%95%ed%95%9c%ec%88%98-%ea%b5%90%ec%88%98-%ea%b3%b5%eb%8f%99-%ec%97%b0%ea%b5%ac%ed%8c%80-%ec%8b%a0%eb%ac%bc%ec%a7%88-77c-%eb%a9%b4%ec%97%ad-%eb%b0%98%ec%9d%91","status":"publish","type":"post","link":"https:\/\/gistnews.co.kr\/?p=7331","title":{"rendered":"\uae40\uc6a9\ucca0\u00b7\ubc15\ud55c\uc218 \uad50\uc218 \uacf5\ub3d9 \uc5f0\uad6c\ud300 \uc2e0\ubb3c\uc9c8 77c, \uba74\uc5ed \ubc18\uc751 \ucd09\uc9c4\ud574 \uc554 \uce58\ub8cc\ud55c\ub2e4"},"content":{"rendered":"

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\"\"
\uc0ac\uc9c4 \uc81c\uacf5 = \uc5f0\uad6c\ud300<\/figcaption><\/figure>\n

 <\/p>\n

\uc9c0\ub09c 10\uc6d4 30\uc77c \uc0dd\uba85\uacfc\ud559\uacfc \uae40\uc6a9\ucca0 \uad50\uc218\uc640 \uc758\uc0dd\uba85\uacf5\ud559\uacfc \ubc15\ud55c\uc218 \uad50\uc218\uc758 GIST \uacf5\ub3d9\uc5f0\uad6c\ud300\uc740 \uc554\uc138\ud3ec\uc758 \uba74\uc5ed \ud68c\ud53c\ub97c \ub3d5\ub294 TPST2 \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud558\ub294 \uc2e0\ubb3c\uc9c8\uc778 \u201877c\u2019\uc5d0 \ub300\ud55c \ub17c\ubb38\uc744 Journal of Medical Chemistry\uc5d0 \uac8c\uc7ac\ud588\ub2e4. \ub300\uc7a5\uc554 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c TPST2 \uc5b5\uc81c\uc81c\ub97c \uae30\uc874 \uba74\uc5ed\ud56d\uc554\uc81c\uc640 \ubcd1\uc6a9\ud588\uc744 \ub54c \ud56d\uc554\uc81c\ub97c \ud22c\uc5ec\ud558\uc9c0 \uc54a\uc740 \ub300\uc870\uad70 \ub300\ube44 \uc885\uc591 \ud06c\uae30\uac00 \uc57d 1\/4 \uc218\uc900\uc73c\ub85c \uac10\uc18c\ud568\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n

 <\/p>\n

\uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ub0ae\uc740 \ucd08\uae30 \ubc18\uc751\ub960\uacfc <\/b>TPST2<\/b><\/p>\n

 <\/p>\n

\uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \ud55c \uc885\ub958\ub85c, T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \uc778\uc2dd\ud558\uace0 \uacf5\uaca9\ud558\ub294 \uacfc\uc815\uc744 \ubc29\ud574\ud558\ub294 \uba74\uc5ed\uad00\ubb38 \ub2e8\ubc31\uc9c8\uc744 \uc5b5\uc81c\ud55c\ub2e4. Anti-PD-1\uacfc \uac19\uc740 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ucd08\uae30 \ubc18\uc751\ub960\uc740 \ud3c9\uade0 15%~45%\ub85c \ub9e4\uc6b0 \ub0ae\ub2e4. \ucd08\uae30 \ubc18\uc751\uc774 \uc77c\uc5b4\ub09c \ud658\uc790\uc758 63%\uac00 5\ub144 \uc774\uc0c1 \uc0dd\uc874\ud588\uae30 \ub54c\ubb38\uc5d0 \ucd08\uae30 \ubc18\uc751\ub960\uc744 \ub192\uc77c \uc218 \uc788\ub2e4\uba74 \ub354 \ub9ce\uc740 \ud658\uc790\ub97c \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ucd08\uae30 \ubc18\uc751\ub960\uc744 \ub192\uc774\ub294 \uac83\uc774 \uba74\uc5ed\ud56d\uc554\uc81c \uac1c\ubc1c\uc758 \uac00\uc7a5 \uc911\uc694\ud55c \uacfc\uc81c\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc774 \ubb38\uc81c\uc5d0 \ub300\ud55c \ud574\uacb0\ucc45\uc73c\ub85c TPST2\uc640 \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \uc77c\uc885\uc778 Interferon-\u03b3(IFN\u03b3) \uc2e0\ud638 \uac04\uc758 \uad00\uacc4\uc5d0 \uc8fc\ubaa9\ud588\ub2e4. IFN\u03b3 \uc2e0\ud638\ub294 \uc554\uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \uc5b5\uc81c\ud558\uace0 \uc138\ud3ec \uc0ac\uba78\uc744 \uc99d\uac00\uc2dc\ud0a4\uba70, \uba74\uc5ed \uc138\ud3ec\uc778 T\uc138\ud3ec\uc5d0 \uc885\uc591 \ud56d\uc6d0\uc744 \uc81c\uc2dc\ud558\ub294 \uacfc\uc815\uc744 \uac15\ud654\ud55c\ub2e4. \ub300\ud45c\uc801\uc778 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc778 Anti-PD-1\uc758 \ubb38\uc81c\uc810\uc778 \ub0ae\uc740 \ucd08\uae30 \ubc18\uc751\ub960\uc740 \uc77c\ubd80 \uc554\uc885\uc5d0\uc11c TPST2\ub85c \uc778\ud55c IFN\u03b3 \uc2e0\ud638 \uac10\uc18c\ub85c \uc778\ud574 \ub098\ud0c0\ub09c\ub2e4\uace0 \uc2e4\ud5d8\ud300\uc740 \uc608\uce21\ud588\ub2e4. \uc77c\ubd80 \uc554\uc5d0\uc11c \ubc1c\ud604\uc774 \ud2b9\ud788 \uc99d\uac00\ud55c \ud6a8\uc18c\uc778 TPST2\ub294 \uc774 IFN\u03b3 \uc2e0\ud638\ub97c \uc57d\ud558\uac8c \ud55c\ub2e4. \uc774\uc640 \uac19\uc740 \uc791\uc6a9\uc740 \uc885\uc591\uc758 \uc720\ud615\uc774\ub098 \ubbf8\uc138\ud658\uacbd \uc870\uac74\uc5d0 \ub530\ub77c \uc554\uc138\ud3ec\uc758 \uba74\uc5ed \ud68c\ud53c\uc5d0 \uad00\uc5ec\ud560 \uac00\ub2a5\uc131\uc774 \uc788\ub2e4. \uc5f0\uad6c\ud300\uc740 TPST2\uc758 \uc791\uc6a9\uc744 \uc5b5\uc81c\ud558\uba74 IFN\u03b3\uc758 \uc2e0\ud638\uac00 \uac15\ud574\uc9c8 \uac83\uc774\uace0, T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \uc778\uc2dd\ud558\ub294 \uacfc\uc815\uc744 \uac15\ud654\ud574 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ub0ae\uc740 \ucd08\uae30 \ubc18\uc751\ub960\uc744 \ub192\uc77c \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ud588\ub2e4. \ub530\ub77c\uc11c \uc5f0\uad6c\ud300\uc740 IFN\u03b3 \uc2e0\ud638\ub97c \uac15\ud654\ud558\uae30 \uc704\ud574 TPST2\uc758 \uc791\uc6a9\uc744 \uc5b5\uc81c\ud558\ub294 \ubb3c\uc9c8\uc744 \ucc3e\uace0\uc790 \uc5f0\uad6c\ub97c \uae30\ud68d\ud588\ub2e4.<\/p>\n

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\uce5c\uc218\uc131\uc744 \uac00\uc9c4 <\/b>77c<\/b>\uc758 \uac1c\ubc1c \uacfc\uc815<\/b><\/p>\n

 <\/p>\n

\uc5f0\uad6c\ud300\uc740 \ucd08\uae30 *\ud788\ud2b8 \ud654\ud569\ubb3c\ub85c 44a\ub97c \uc120\uc815\ud588\ub2e4. 44a\ub294 \ud55c\uad6d\ud654\ud569\ubb3c\uc740\ud589\uc758 \ud654\ud569\ubb3c \ub77c\uc774\ube0c\ub7ec\ub9ac\uc758 \ud654\ud569\ubb3c \uc911 \ud6a8\ub2a5 \ud3c9\uac00 \uacb0\uacfc TPST2 \ud6a8\uc18c \uc5b5\uc81c \ub2a5\ub825\uc774 \uac00\uc7a5 \uc6b0\uc218\ud55c \ubb3c\uc9c8\uc774\ub2e4. \ud2b9\ud788 44a\ub294 \uc57d\ud6a8\ub97c \uacb0\uc815\ud558\ub294 \ud575\uc2ec \uad6c\uc870\uc778 \ucf54\uc5b4 \uad6c\uc870 \ub610\ud55c \uac00\uc9c0\uace0 \uc788\uc5b4 \uc57d\ubb3c \uac1c\ubc1c\uc758 \uc131\uacf5 \uac00\ub2a5\uc131\uc774 \ub192\uc544 \uad6c\uc870 \uc720\uc0ac\uccb4 \ud569\uc131 \uc5f0\uad6c\uc5d0 \uc720\ub9ac\ud558\ub2e4. \uadf8\ub7ec\ub098 44a\uc758 \uad6c\uc870\uc801 \uc694\uc18c\ub4e4\uc774 \ud3c9\ud3c9\ud55c \ud310 \ubaa8\uc591\uc73c\ub85c \ub3fc \uc788\uc5b4 \uadf9\uc131\uc744 \ub744\uc9c0 \uc54a\uc544 \ubb3c\uc5d0 \uc798 \ub179\uc9c0 \uc54a\ub294\ub2e4\ub294 \ub2e8\uc810\uc774 \uc788\ub2e4. \uc774\uc5d0 \ub530\ub77c 44a\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \uacbd\uad6c\uc57d\uc744 \ub9cc\ub4e4\uc5c8\uc744 \ub54c \ud608\uc561\uc5d0 \ub179\uc9c0 \ubabb\ud574 \ud608\uad00\uc744 \ud1b5\ud574 \uc2e0\uccb4 \ub0b4\uc5d0\uc11c \uc6c0\uc9c1\uc774\uae30 \ud798\ub4e4\ub2e4\ub294 \ub2e8\uc810\uc774 \uc788\uc5c8\ub2e4.<\/p>\n

\ub530\ub77c\uc11c \uc5f0\uad6c\ud300\uc740 \uc704 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \uad6c\uc870-\ud65c\uc131\ud654 \uad00\uacc4 (SAR) \ucd5c\uc801\ud654 \uc5f0\uad6c\ub97c \uc9c4\ud589\ud588\ub2e4. \uce5c\uc218\uc131 \uce58\ud658\uae30\ub97c \ub3c4\uc785\ud558\uace0, \uae30\ubcf8 \uad6c\uc870\uc5d0 **\ud53c\ud398\ub77c\uc9c4\uacfc \uac19\uc740 \ub2e4\ub978 \ud654\ud569\ubb3c\ub4e4\uc744 \uc0bd\uc785\ud574 \ud310\uc0c1\uad6c\uc870\uc5d0\uc11c \ubc97\uc5b4\ub098\uac8c \ud588\ub2e4. \uadf8 \uacb0\uacfc \ub2e4\uc591\ud55c \uad6c\uc870 \uc720\uc0ac\uccb4 \uc911 44a\uc758 \uc6a9\ud574\ub3c4\uc640 \ud761\uc218\uc728\uc774 \uac1c\uc120\ub41c 77c\ub97c \ud569\uc131\ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4.<\/p>\n

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77c<\/b>\ub97c \ud1b5\ud55c \uba74\uc5ed \ubc18\uc751 \uac15\ud654\uc640 \ud56d\uc554 \ud6a8\uacfc<\/b><\/p>\n

C-X-C \ubaa8\ud2f0\ud504 \ucf00\ubaa8\uce74\uc778 \ub9ac\uac04\ub4dc 10(\uc774\ud558 CXCL10)\uc740 IFN\u03b3 \uc720\ub3c4 \ub2e8\ubc31\uc9c810(IP-10)\uc774\ub77c\uace0\ub3c4 \ubd88\ub9ac\ub294 \ub2e8\ubc31\uc9c8\ub85c, IFN\u03b3\ub4f1 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \uc2e0\ud638\uc5d0 \ubc18\uc751\ud574 \ub2e8\ud575\uad6c, \ub0b4\ud53c\uc138\ud3ec \ub4f1\uc5d0\uc11c \ubd84\ube44\ub41c\ub2e4. CXCL10\uc740 \uba74\uc5ed\uc138\ud3ec\uc778 T\uc138\ud3ec, \ub300\uc2dd\uc138\ud3ec, NK\uc138\ud3ec \ubc0f \uc218\uc9c0\uc0c1 \uc138\ud3ec\uc5d0 \ub300\ud55c \ud654\ud559\uc801 \uc720\uc778\uc744 \ud1b5\ud574 \ud56d\uc885\uc591 \ud65c\uc131 \ub4f1\uc758 \uc5ed\ud560\uc744 \ud55c\ub2e4. 77c\uc758 \uc791\uc6a9\uc744 \ud1b5\ud574 TPST2\uac00 \uc5b5\uc81c\ub418\uace0, IFN\u03b3 \uc2e0\ud638\uac00 \ud68c\ubcf5\ub3fc CXCL10\uc758 mRNA \ubc1c\ud604\uc774 \uc810\uc810 \uc99d\uac00\ud558\ub294 \uacbd\ud5a5\uc774 \uad00\ucc30\ub410\ub2e4. CXCL10\uc774 \uc99d\uac00\ud558\uba74\uc11c ***CD8+ T\uc138\ud3ec\uc758 \uc218\uac00 \ub298\uc5b4\ub0ac\uace0, \uc885\uc591\uc758 \ud06c\uae30 \ub610\ud55c \ub300\uc870\uad70\uc5d0 \ube44\ud574 \ub354 \uac10\uc18c\ud588\ub2e4.<\/p>\n

\uc2e4\ud5d8\uc758 \uacb0\uacfc\uc778 \uc704 \uc774\ubbf8\uc9c0\uc758 CXCL10\uacfc \uad00\ub828\ub41c \uadf8\ub798\ud504\ub97c \ubcf4\uba74, 77c\uc758 \ub18d\ub3c4\uac00 \uc99d\uac00\ud560\uc218\ub85d CXCL10\uc5d0 \ud574\ub2f9\ud558\ub294 mRNA \ubc1c\ud604\uc774 \uc99d\uac00\ud558\ub294 \ub18d\ub3c4 \uc758\uc874\uc801 \uacbd\ud5a5\uc774 \ub098\ud0c0\ub0ac\ub2e4. \ub610\ud55c \ub0a0\uc9dc\uc5d0 \ub530\ub978 \uc554\uc758 \ud06c\uae30\uc640 \uad00\ub828\ub41c \uadf8\ub798\ud504\uc5d0 \ub530\ub974\uba74 \ucd1d 4\uac00\uc9c0\uc758 \uaebe\uc740\uc120 \uadf8\ub798\ud504\ub97c \ubd84\uc11d\ud588\uc744 \ub54c \ub300\uc870\uad70, 77c \ud639\uc740 Anti-PD-1 \ub2e8\ub3c5 \ucc98\ub9ac\uad70, \uadf8\ub9ac\uace0 77c\uc640 Anti-PD-1\ub97c \ubcd1\uc6a9 \ucc98\ub9ac\uad70 \uc21c\uc73c\ub85c \ub354 \uc791\uc544\uc9c0\ub294 \uac83\uc774 \uad00\ucc30 \ub410\ub2e4. \uadf8\ub9ac\uace0 CD8+ T\uc138\ud3ec \uc218\uc758 \uacbd\uc6b0 \uc704 \uc21c\uc11c\ub300\ub85c \ub354 \ub9ce\uc544\uc9c0\ub294 \uac83\uc744 \ud655\uc778\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ub530\ub77c\uc11c 77c\ub294 IFN\u03b3 \uc2e0\ud638\ub97c \uac15\ud654\ud574 CXCL10 mRNA\ub97c \ud65c\uc131\ud654\ud558\uace0, \uc774\ub97c \ud1b5\ud574 \uba74\uc5ed \ubc18\uc751\uc774 \ub354 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub3c4\ub85d \ud55c\ub2e4\ub294 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \ub610\ud55c 77c\ub294 Anti-PD-1 \uce58\ub8cc\uc5d0 \ubcd1\ud589\ud574 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \uc5bb\uc744 \uc218 \uc788\uc74c\uc774 \uad00\ucc30\ub410\ub2e4. 77c\uc758 \ucd94\uac00\uc801\uc778 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \ub2e4\uc74c \ub0b4\uc6a9\uc5d0\uc11c \uc124\uba85\ud558\uace0\uc790 \ud55c\ub2e4.<\/p>\n

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\u201877c\u2019<\/b>\ub97c \ud65c\uc6a9\ud55c <\/b>TPST2 <\/b>\uc800\ud574\uc81c\uc640 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \uc2dc\ub108\uc9c0 \ud6a8\uacfc<\/b><\/p>\n

77c\uc758 \ud45c\uc801 \ubb3c\uc9c8\uc778 TPST2 \ud6a8\uc18c\ub294 \ud2b9\uc815 \uc554\uc5d0\uc11c \ubc1c\ud604\uc774 \uc99d\uac00\ud55c\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc720\ubc29\uc554\uacfc \ub300\uc7a5\uc554\uc758 \uc99d\uc2dd\uc5d0 TPST2\uc758 \uc601\ud5a5\uc774 \uc788\ub2e4\ub294 \uac83\uc744 \uc2e4\ud5d8\uc744 \ud1b5\ud574 \uc9d0\uc791\ud588\ub2e4. \ub300\uaddc\ubaa8 \ub370\uc774\ud130 \ubd84\uc11d\uc5d0\uc11c\ub294 \uc774 \ub450 \uc554\uc885\ubfd0\ub9cc \uc544\ub2c8\ub77c \ub450\uacbd\ubd80\uc554, \ub09c\uc18c\uc554, \uc704\uc554, \uc790\uad81\ub0b4\ub9c9\uc554 \ub4f1 \uc5ec\ub7ec \uc554\uc885\uc5d0\uc11c TPST2 \ubc1c\ud604 \uc99d\uac00 \ud604\uc0c1\uc774 \ub098\ud0c0\ub0ac\ub2e4. \uc55e\uc11c \ub098\uc5f4\ud55c \ud2b9\uc815 \uc554\ub4e4\uc740 Anti-PD-1\uc744 \uc774\uc6a9\ud55c PD-1 \uce58\ub8cc\ub97c \uc9c4\ud589\ud55c\ub2e4. 77c\ub97c \uae30\ubc18\uc73c\ub85c \ud55c TPST2 \uc800\ud574\uc81c\ub294 PD-1 \uce58\ub8cc\uc5d0 \ub3c4\uc6c0\uc744 \uc900\ub2e4.<\/p>\n

PD-1 \uce58\ub8cc\uc5d0\uc11c \uc554\uc138\ud3ec\uac00 \uc0ac\uba78\ub418\ub294 \uacfc\uc815\uc740 \ub2e4\uc74c\uacfc \uac19\ub2e4. \uc6b0\uc120 T\uc138\ud3ec\ub294 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud574 \uc554\uc138\ud3ec\ub97c \uc81c\uac70\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc554\uc138\ud3ec\uc758 \ud45c\uba74\uc5d0 \uc788\ub294 PD-L1\uc740 T\uc138\ud3ec\uc758 \uba74\uc5ed \ubc18\uc751\uc774 \uacfc\ub3c4\ud558\uac8c \uc9c4\ud589\ub418\uc9c0 \uc54a\ub3c4\ub85d \uc5b5\uc81c\ud55c\ub2e4. T\uc138\ud3ec\uc758 PD-1 \ub2e8\ubc31\uc9c8\uacfc \uacb0\ud569\ud574 T\uc138\ud3ec\uac00 \uae30\ub2a5\ud558\uc9c0 \ubabb\ud558\ub3c4\ub85d \ub9c9\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \ub530\ub77c\uc11c \ud56d\uccb4\uc778 Anti-PD-1\uc740 T\uc138\ud3ec\uc758 PD-1 \ub2e8\ubc31\uc9c8\uc774 PD-L1\uacfc\uc758 \uacb0\ud569\uc744 \ucc28\ub2e8\ud574 T\uc138\ud3ec\uc758 \uae30\ub2a5 \uc5b5\uc81c\ub97c \uc644\ud654\ud574 T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud560 \uc218 \uc788\ub3c4\ub85d \ud55c\ub2e4. TPST2 \uc5b5\uc81c\uc81c\ub294 \uc704 \uce58\ub8cc \uacfc\uc815\uc744 \ub354 \uc6d0\ud65c\ud558\uac8c \uc77c\uc5b4\ub098\ub3c4\ub85d \ub3d5\ub294\ub2e4. TPST2\uc758 \uc2e0\ud638\uac00 \uc57d\ud574\uc9c0\uba74 \uc554\uc138\ud3ec\ub294 IFN\u03b3\uc5d0 \ubbfc\uac10\ud574\uc838 T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \uc778\uc2dd\ud558\uac8c \ud574\uc8fc\ub294 \uacfc\uc815\uc778 \ud56d\uc6d0\uc81c\uc2dc\ub97c \uc704\ud55c \ubd84\uc790\ub4e4\uc758 \ubc1c\ud604\uc774 \uc99d\uac00\ud558\ub3c4\ub85d \ud55c\ub2e4. \uc815\ub9ac\ud558\uba74 TPST2 \uc5b5\uc81c\uc81c\ub294 \ud56d\uc6d0\uc81c\uc2dc \ubd84\uc790\ub97c \ub298\ub824 \ud56d\uc6d0\uc81c\uc2dc \uacfc\uc815\uc744 \ub3d5\uace0, \uba74\uc5ed\ud56d\uc554\uc81c\uc778 Anti-PD-1\uc740 \uc138\ud3ec\ub3c5\uc131 T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \ud30c\uad34\ud558\ub294 \uacfc\uc815\uc774 \uc9c0\uc18d\uc801\uc73c\ub85c \uc77c\uc5b4\ub098\ub3c4\ub85d \ub3d5\ub294\ub2e4.<\/p>\n

Anti-PD-1 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc740 \ub2e8\uc21c\ud788 T\uc138\ud3ec\uc758 \uae30\ub2a5 \ubd80\uc804\ubfd0\ub9cc \uc544\ub2c8\ub77c, \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc758 \uba74\uc5ed \uc5b5\uc81c\uc801 \ubcc0\ud654, \ud45c\uba74 \ud56d\uc6d0\uc758 \uc18c\uc2e4 \ub4f1\uc758 \ub2e4\uc591\ud55c \ubcf5\ud569\uc801 \uc694\uc778\uc5d0 \uc758\ud574 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4. \uc5f0\uad6c\ud300\uc740 TPST2 \uc5b5\uc81c\uc81c\uac00 Anti-PD-1 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc774 \uc0dd\uae34 \ud658\uc790\ub97c \ub3c4\uc6b8 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \ud3c9\uac00\ud55c\ub2e4. Anti-PD-1 \uce58\ub8cc \uacfc\uc815\uc5d0\uc11c \ubc18\uc751\uc774 \uc5c6\uac70\ub098 \uc800\ud56d\uc774 \uc0dd\uae34 \uacbd\uc6b0, \uadf8\ub9ac\uace0 \uba74\uc5ed \uc138\ud3ec\uc758 \uae30\ub2a5\uc774 \ub5a8\uc5b4\uc9c4 \uacbd\uc6b0 \ud658\uc790\ub4e4\uc758 \uba74\uc5ed\uc138\ud3ec\ub4e4\uc774 \ub2e4\uc2dc \uc554\uc138\ud3ec\ub97c \uc778\uc2dd\ud560 \ub54c TPST2 \uc5b5\uc81c\uc81c\uac00 \ub3c4\uc6c0\uc744 \uc904 \uac00\ub2a5\uc131\uc774 \uc81c\uc2dc\ub410\ub2e4. \uc5f0\uad6c\ud300\uc740 \ud2b9\ud788 \uc0bc\uc911\uc74c\uc131\uc720\ubc29\uc554(\uc774\ud558 TNBC)\uc758 \uacbd\uc6b0 \uc774 \ud6a8\uacfc\uac00 \ub354 \uc798 \ub098\ud0c0\ub09c\ub2e4\uace0 \ubcf8\ub2e4. TNBC\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\uc778 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ubc18\uc751\ub960\uc774 \ub0ae\uc740 \uc554\uc885\uc774\ub2e4. \uc774 \ud658\uc790\uc5d0\uc11c TPST2 \uc5b5\uc81c\uc81c\ub97c \ubcd1\uc6a9\ud558\uba74 \ud56d\uc6d0\uc81c\uc2dc\uc640 T\uc138\ud3ec\uc758 \uce68\ud22c\ub97c \ub3d9\uc2dc\uc5d0 \ub192\uc5ec\uc904 \uc218 \uc788\ub294 \ubcf4\uc644 \uc804\ub7b5\uc774 \ub41c\ub2e4\uace0 \uc608\uce21\ud588\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c\uc640 \ubcd1\uc6a9\ud588\uc744 \uc2dc\uc5d0 \uc548\uc804\uc131 \uc6b0\ub824\ub85c\ub294 \uc790\uac00\uba74\uc5ed \ubc18\uc751\uc774\ub098 \uacfc\ub3c4\ud55c \uc5fc\uc99d\uc5d0 \ub300\ud55c \uc8fc\uc758\uac00 \ud544\uc694\ud558\ub2e4\ub294 \uc810\uc774 \uc788\ub2e4. IFN\u03b3 \uc2e0\ud638\ub97c \uc9c0\ub098\uce58\uac8c \uc62c\ub9ac\uba74 \uc870\uc9c1 \uc190\uc0c1\uc774\ub098 \uc804\uc2e0 \uc5fc\uc99d \ubc18\uc751\uc774 \uc77c\uc5b4\ub0a0 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \ub2e4\ub9cc TPST2 \uc5b5\uc81c\ub294 \uc804\uc2e0 \uba74\uc5ed\uacc4\ub97c \uc790\uadf9\ud558\ub294 \uac83\ubcf4\ub2e4 \uc885\uc591\uc138\ud3ec\uc758 IFN\u03b3 \ubc18\uc751\uc131\uc744 \ub192\uc774\uace0, \ud56d\uc6d0\uc81c\uc2dc \ubc0f T\uc138\ud3ec \uc778\uc2dd \uac15\ud654\uc5d0 \ucd08\uc810\uc774 \ub9de\ucdb0\uc838 \uc788\ub2e4. \ub530\ub77c\uc11c \uc5f0\uad6c\ud300\uc740 TPST2 \uc5b5\uc81c\uc81c\uc758 \uba74\uc5ed \uc870\uc808\uc740 \uc8fc\ub85c \uc885\uc591\uc138\ud3ec\uc758 IFN\u03b3 \ubc18\uc751\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \ubc29\ud5a5\uc73c\ub85c \uc791\uc6a9\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4\uace0 \ud3c9\uac00\ud55c\ub2e4.<\/p>\n

 <\/p>\n

\uc774\ud6c4 \uc5f0\uad6c \uacc4\ud68d<\/b><\/p>\n

\uc5f0\uad6c\ud300\uc740 77c\uc758 \ud6c4\uc18d \ubb3c\uc9c8\ub85c \uc57d\ubb3c \ucd5c\uc801\ud654\ub97c \uc704\ud574 \uc5f0\uad6c\ub97c \uc9c4\ud589 \uc911\uc774\ub2e4. \ud6c4\uc18d \ubb3c\uc9c8\uc740 \uc57d\ubb3c\uc758 \ud65c\uc131\uacfc \ubb3c\uc131 \ubaa8\ub450 77c\ubcf4\ub2e4 \uac1c\uc120\ub41c \uc9c0\ud45c\ub4e4\uc744 \ubcf4\uc5ec \ucd94\uac00 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ud6c4\ubcf4 \ubb3c\uc9c8\ub85c \uac1c\ubc1c\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4. \ud604\uc7ac TPST2 \ub2e8\ubc31\uc9c8\uc740 \ub3d9\ubb3c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc0dd\uc2dd\uc120 \ubc0f \uac11\uc0c1\uc120\uc5d0 \ub9ce\uc740 \ubc1c\ud604\uc774 \ub098\ud0c0\ub09c\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub2e4. \ub9c8\uc6b0\uc2a4\ub97c \uc774\uc6a9\ud55c ****\uc720\uc804\uc790 \ub179\uc544\uc6c3 \uc5f0\uad6c \uacb0\uacfc TPST2 \ud6a8\uc18c\ub97c \ub9cc\ub4dc\ub294 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud588\uc744 \ub54c \uac11\uc0c1\uc0d8\uc800\ud558\uc99d\uc774 \ub098\ud0c0\ub0ac\ub2e4. \uc774\uc5d0 \ub530\ub77c \ud5a5\ud6c4 \uc784\uc0c1 \ud6c4\ubcf4 \ubb3c\uc9c8\uc774 \ub3c4\ucd9c\ub420 \uacbd\uc6b0, \uc678\uc778\uc131 \uc57d\ubb3c\uc5d0 \uc758\ud55c \ub3c5\uc131\uc744 \uba74\ubc00\ud788 \uac80\uc99d\ud560 \ud544\uc694\uac00 \uc788\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc784\uc0c1 \ud6c4\ubcf4 \ubb3c\uc9c8 \ub2e8\uacc4\uc758 \uc57d\ubb3c\uc744 \ud569\uc131\ud560 \uacbd\uc6b0 \ub3c5\uc131 \uc5f0\uad6c\ub97c \uc9c4\ud589\ud560 \uacc4\ud68d\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

 <\/p>\n

*\ud788\ud2b8 \ud654\ud569\ubb3c:\ud45c\uc801 \ub2e8\ubc31\uc9c8\uc5d0 \ub300\ud574 \ucc98\uc74c\uc73c\ub85c \uc720\uc758\ubbf8\ud55c \uc57d\ub9ac \ud65c\uc131\uc744 \ubcf4\uc778 \ucd08\uae30 \ubb3c\uc9c8<\/p>\n

**\ud53c\ud398\ub77c\uc9c4: \ubc18\ub300 \uc704\uce58\uc5d0 \uc9c8\uc18c \uc6d0\uc790\ub97c \ud3ec\ud568\ud55c 6\uc6d0 \uace0\ub9ac\uc758 \uc720\uae30 \ud654\ud569\ubb3c<\/p>\n

***CD8+ T\uc138\ud3ec: \uc138\ud3ec\ub3c5\uc131 T\ub9bc\ud504\uad6c\ub77c\uace0\ub3c4 \ud558\uba70, \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uac10\uc5fc\ub41c \uc138\ud3ec\ub098 \uc885\uc591 \uc138\ud3ec \ub4f1\uc758 \ube44\uc815\uc0c1 \uc138\ud3ec\ub97c \uc9c1\uc811 \uc778\uc2dd\ud558\uace0 \uc81c\uac70\ud558\ub294 \uc138\ud3ec<\/p>\n

****\uc720\uc804\uc790 \ub179\uc544\uc6c3(knockout): \uc5b4\ub5a4 \uc720\uae30\uccb4\uc758 \uc720\uc804\uc790\uac00 \uc791\ub3d9\ud558\uc9c0 \uc54a\ub3c4\ub85d \ud558\ub294 \uc720\uc804\ud559\uc801 \uae30\uc220<\/p>\n","protected":false},"excerpt":{"rendered":"

    \uc9c0\ub09c 10\uc6d4 30\uc77c \uc0dd\uba85\uacfc\ud559\uacfc \uae40\uc6a9\ucca0 \uad50\uc218\uc640 \uc758\uc0dd\uba85\uacf5\ud559\uacfc \ubc15\ud55c\uc218 \uad50\uc218\uc758 GIST \uacf5\ub3d9\uc5f0\uad6c\ud300\uc740 \uc554\uc138\ud3ec\uc758 \uba74\uc5ed \ud68c\ud53c\ub97c \ub3d5\ub294 TPST2 \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud558\ub294 \uc2e0\ubb3c\uc9c8\uc778 \u201877c\u2019\uc5d0 \ub300\ud55c \ub17c\ubb38\uc744 Journal of Medical Chemistry\uc5d0 \uac8c\uc7ac\ud588\ub2e4. \ub300\uc7a5\uc554 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c TPST2 \uc5b5\uc81c\uc81c\ub97c \uae30\uc874 \uba74\uc5ed\ud56d\uc554\uc81c\uc640 \ubcd1\uc6a9\ud588\uc744 \ub54c \ud56d\uc554\uc81c\ub97c \ud22c\uc5ec\ud558\uc9c0 \uc54a\uc740 \ub300\uc870\uad70 \ub300\ube44 \uc885\uc591 \ud06c\uae30\uac00 \uc57d 1\/4 \uc218\uc900\uc73c\ub85c \uac10\uc18c\ud568\uc744 \ud655\uc778\ud588\ub2e4.   \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc758 \ub0ae\uc740 \ucd08\uae30 \ubc18\uc751\ub960\uacfc […]<\/p>\n","protected":false},"author":192,"featured_media":7332,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_post_was_ever_published":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[32,248,81],"tags":[],"coauthors":[405],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/gistnews.co.kr\/wp-content\/uploads\/2026\/03\/photo-scaled.jpeg?fit=2560%2C968&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pdL9j0-1Uf","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7331"}],"collection":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/users\/192"}],"replies":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7331"}],"version-history":[{"count":1,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7331\/revisions"}],"predecessor-version":[{"id":7333,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7331\/revisions\/7333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/media\/7332"}],"wp:attachment":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7331"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcoauthors&post=7331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}