{"id":7465,"date":"2026-07-25T01:28:47","date_gmt":"2026-07-24T16:28:47","guid":{"rendered":"https:\/\/gistnews.co.kr\/?p=7465"},"modified":"2026-07-25T01:28:47","modified_gmt":"2026-07-24T16:28:47","slug":"%ec%b5%9c%ec%a7%84%ec%9a%b1-%ea%b5%90%ec%88%98-%ec%97%b0%ea%b5%ac%ed%8c%80-%ed%8f%90%ec%95%94%ec%9d%98-%ec%a2%85%ec%96%91-%ec%b9%9c%ed%99%94%ec%a0%81-%eb%af%b8%ec%84%b8%ed%99%98","status":"publish","type":"post","link":"https:\/\/gistnews.co.kr\/?p=7465","title":{"rendered":"\ucd5c\uc9c4\uc6b1 \uad50\uc218 \uc5f0\uad6c\ud300, \ud3d0\uc554\uc758 \u2018\uc885\uc591 \uce5c\ud654\uc801\u2019 \ubbf8\uc138\ud658\uacbd \ud615\uc131\uc744 \uaddc\uba85\ud558\ub2e4"},"content":{"rendered":"
\"\"
\uc0ac\uc9c4 \uc81c\uacf5 = GIST \uc720\ub2e4\uc5f0 \ud559\uc0dd<\/figcaption><\/figure>\n

GIST \uc0dd\uba85\uacfc\ud559\uacfc \ucd5c\uc9c4\uc6b1 \uad50\uc218 \uc5f0\uad6c\ud300\uc774 \ud3d0\uc554\uc758 \u2018\uc554\uc774 \uc790\ub77c\uae30 \uc26c\uc6b4 \ud658\uacbd\u2019 \ud615\uc131 \uacfc\uc815\uc744 \uaddc\uba85\ud588\ub2e4. \ud3d0\uc554\uc774 \ubcf8\uaca9\uc801\uc778 \uc885\uc591\uc73c\ub85c \uc131\uc7a5\ud558\uae30 \uc774\uc804\ubd80\ud130 \uc8fc\ubcc0 \uc870\uc9c1\uc774 \uc554 \uc131\uc7a5\uc5d0 \uc720\ub9ac\ud55c \ud658\uacbd\uc73c\ub85c \ubcc0\ud654\ud558\ub294 \uacfc\uc815\uc744 \ubc1d\ud78c \uac83\uc774\ub2e4. \uc774\ubc88 \uc5f0\uad6c \uc131\uacfc\ub294 \uc554 \uc608\ubc29\uc5d0 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud574 2026\ub144 4\uc6d4 22\uc77c \uad6d\uc81c \ud559\uc220\uc9c0 <\ub124\uc774\ucc98(Nature)>\uc5d0 \uac8c\uc7ac\ub410\ub2e4.<\/p>\n

 <\/p>\n

\uc554\uc740 \ud63c\uc790 \uc790\ub77c\uc9c0 \uc54a\ub294\ub2e4<\/b><\/p>\n

\uc554\uc740 \uc6b0\ub9ac \ubab8\uc758 \uc138\ud3ec\uac00 \uc720\uc804\uc790 \ubcc0\uc774\ub85c \uc778\ud574 \ubb34\ubd84\ubcc4\ud558\uac8c \uc99d\uc2dd\ud558\uc5ec \uc0dd\uba85\uc744 \uc704\ud611\ud558\ub294 \uc9c8\ubcd1\uc774\ub2e4. \uc554 \uc5f0\uad6c\ub294 \uc624\ub79c \uae30\uac04 \uc554\uc138\ud3ec\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ubc0f \uc99d\uc2dd \uacfc\uc815\uc5d0 \uc9d1\uc911\ud588\ub2e4. \ud3d0\uc554\uc758 \uc8fc\uc694 \uc6d0\uc778\uc73c\ub85c\ub294 \ub300\ud45c\uc801\uc73c\ub85c EGFR*, KRAS** \uc720\uc804\uc790\uc758 \ubcc0\uc774\uac00 \uc54c\ub824\uc838 \uc788\ub2e4. \uadf8\ub7ec\ub098 \ucd5c\uadfc\uc5d0\ub294 \uc554\uc138\ud3ec\ub9cc\uc73c\ub85c\ub294 \uc885\uc591\uc758 \ud615\uc131\u0387\uc720\uc9c0\uac00 \uc5b4\ub835\ub2e4\ub294 \uc810\uc774 \uc8fc\ubaa9\ubc1b\ub294\ub2e4.<\/p>\n

\uc554\uc740 \ub2e8\uc21c\ud788 \ub3cc\uc5f0\ubcc0\uc774 \uc138\ud3ec \ud558\ub098\uac00 \ub3c5\ub9bd\uc801\uc73c\ub85c \uc131\uc7a5\ud558\ub294 \uc9c8\ud658\uc774 \uc544\ub2cc, \uc8fc\ubcc0 \ud658\uacbd\uacfc \uc0c1\ud638 \uc791\uc6a9\ud558\uba70 \uc131\uc7a5\ud558\ub294 \uc9c8\ubcd1\uc774\ub2e4. \uc554\uc138\ud3ec \uc8fc\ubcc0\uc5d0\ub294 \ud608\uad00\uc138\ud3ec***, \uc12c\uc720\uc544\uc138\ud3ec(fibroblast)****, \ub300\uc2dd\uc138\ud3ec(macrophage)*****, \uc138\ud3ec\uc678\uae30\uc9c8(extracellular matrix, ECM)****** \ub4f1 \uc218\ub9ce\uc740 \uad6c\uc870\ubb3c\uacfc \uc138\ud3ec\uac00 \uc874\uc7ac\ud55c\ub2e4. \uc774\ub7ec\ud55c \uc8fc\ubcc0 \ud658\uacbd \uc804\uccb4\ub97c \ud1b5\ud2c0\uc5b4 \uc885\uc591 \ubbf8\uc138\ud658\uacbd(tumor microenvironment, TME)\uc774\ub77c \ubd80\ub978\ub2e4. \ucd5c\uadfc \uc5ec\ub7ec \uc5f0\uad6c\uc5d0\uc11c \uc554\uc138\ud3ec\uac00 \uc8fc\ubcc0 \uc870\uc9c1\uacfc \uc2e0\ud638\ub97c \uc8fc\uace0\ubc1b\uc73c\uba70 \uc131\uc7a5\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc9c0\uace0 \uc788\ub2e4. \ud2b9\ud788 \uc12c\uc720\ud654(fibrosis)\uc640 \uc554\uc758 \uad00\uacc4\uac00 \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4. \uc12c\uc720\ud654\ub294 \uc870\uc9c1 \uc190\uc0c1 \ud6c4 \ud68c\ubcf5 \uacfc\uc815\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \uc815\uc0c1\uc801\uc778 \uce58\uc720 \ubc18\uc751\uc774\ub2e4. \uadf8\ub7ec\ub098 \uc5fc\uc99d \ubc18\uc751\uc774 \ub9cc\uc131\ud654\ub420 \uacbd\uc6b0, \uc12c\uc720\uc544\uc138\ud3ec\uac00 \uacfc\ud558\uac8c \ud65c\uc131\ud654\ub3fc \uc870\uc9c1\uc774 \ub531\ub531\ud558\uac8c \uad73\ub294 \uc12c\uc720\ud654\ub85c \uc774\uc5b4\uc838 \uc815\uc0c1 \uc870\uc9c1 \uad6c\uc870\ub97c \ud30c\uad34\ud55c\ub2e4. \ud3d0 \uc12c\uc720\ud654 \ud658\uc790\uc5d0\uc11c \ud3d0\uc554 \ubc1c\ubcd1\ub960\uc774 \uc99d\uac00\ud55c\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\ub3c4 \uc788\ub2e4.<\/p>\n

\uae30\uc874 \uc554 \uc5f0\uad6c\ub294 \ub300\ubd80\ubd84 \uc774\ubbf8 \ub9cc\ub4e4\uc5b4\uc9c4 \uc885\uc591 \uc790\uccb4 \ub610\ub294 \uc8fc\ubcc0 \ud658\uacbd\uc744 \ubd84\uc11d\ud558\ub294 \ub370\uc5d0 \uc9d1\uc911\ud558\uba70 \ucd08\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc8fc\ubcc0 \uc870\uc9c1\uc774 \uc5b4\ub5bb\uac8c \ubcc0\ud654\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc0c1\ub300\uc801\uc73c\ub85c \ubd80\uc871\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ud6c4\uc790\uc778 \ucd08\uae30 \ubcc0\ud654 \uacfc\uc815\uc5d0 \uc9d1\uc911\ud588\ub2e4.<\/p>\n

 <\/p>\n

\ud3d0 \uc12c\uc720\ud654 \uc5f0\uad6c\uc5d0\uc11c \uc2dc\uc791\ub41c \uc9c8\ubb38<\/b><\/p>\n

\uc774\ubc88 \uc5f0\uad6c\ub294 \ud3d0\uc12c\uc720\uc99d \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \uc774\uc6a9\ud55c \uc5f0\uad6c \uc911 \ubc1c\uacac\ud55c \ud604\uc0c1\uc5d0\uc11c \uc2dc\uc791\ub410\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ud3d0\uc5d0 \uc190\uc0c1\uc774 \ubc1c\uc0dd\ud558\uba74 \uc904\uae30\uc138\ud3ec*******\uac00 \ud65c\uc131\ud654\ub418\uace0, \uc77c\uc2dc\uc801\uc778 \uc911\uac04 \ubd84\ud654 \ub2e8\uacc4\uc778 \uc774\ud589 \uc138\ud3ec (transition cell)\ub97c \uac70\uccd0 \uc815\uc0c1 \ud3d0\uc138\ud3ec\ub85c \ubd84\ud654\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc5f0\uad6c\uc9c4\uc740 \ud3d0 \uc12c\uc720\ud654\uac00 \uc9c4\ud589\ub41c \uc870\uc9c1\uc5d0\uc11c \uc904\uae30\uc138\ud3ec\uac00 \uc815\uc0c1 \ud3d0\uc138\ud3ec\ub85c \ubd84\ud654\ud558\ub294 \uacfc\uc815\uc774 \uc6d0\ud65c\ud558\uac8c \uc9c4\ud589\ub418\uc9c0 \uc54a\uace0, \uc77c\uc2dc\uc801\uc73c\ub85c \uc874\uc7ac\ud574\uc57c \ud558\ub294 \uc774\ud589\uc138\ud3ec \uc0c1\ud0dc\uc5d0 \uc9c0\uc18d\uc801\uc73c\ub85c \uba38\ubb34\ub978\ub2e4\ub294 \uc810\uc744 \ubc1c\uacac\ud588\ub2e4. \uc774\ud6c4 \uc778\uac04 \ud3d0\uc120\uc554 \ud658\uc790 \uc870\uc9c1\uc744 \ubd84\uc11d\ud55c \uacb0\uacfc, \ud3d0\uc554 \uc870\uc9c1\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \u2018\uc77c\uc2dc\uc801 \uc138\ud3ec \uc9d1\ub2e8(transient cell population)\u2019\uc774 \uc874\uc7ac\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub97c \ubc14\ud0d5\uc73c\ub85c \ud3d0\uc12c\uc720\ud654\uc640 \ud3d0\uc554\uc774 \uc77c\ubd80 \uacf5\ud1b5\ub41c \uc870\uc9c1 \ubcc0\ud654 \uacfc\uc815\uc744 \uacf5\uc720\ud560 \uac00\ub2a5\uc131\uc5d0 \uc8fc\ubaa9\ud588\ub2e4.<\/p>\n

 <\/p>\n

\uc554\ubcf4\ub2e4 \uba3c\uc800 \ud615\uc131\ub41c <\/b>\u2018<\/b>\uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd<\/b>\u2019<\/b><\/p>\n

\uc554\uc138\ud3ec\ub294 \ubcf8\uaca9\uc801\uc778 \uc99d\uc2dd \uc774\uc804, \uc8fc\ubcc0 \ud658\uacbd\uc744 \u2018\uc885\uc591 \uce5c\ud654\uc801 \ubbf8\uc138\ud658\uacbd\u2019\uc73c\ub85c \ubc14\uafbc\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub7ec\ud55c \ud658\uacbd\uc744 \u2018\uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd(fibrotic niche)\u2019\ub77c\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 KRAS \ubcc0\uc774\ub97c \uac00\uc9c4 \ud3d0\ud3ec \uc0c1\ud53c\uc138\ud3ec\uc778 AT2(alveolar type II)******** \uc138\ud3ec \uc8fc\ubcc0\uc5d0\uc11c \uc815\uc0c1 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \ubcd1\ub9ac\uc801 \uc0c1\ud0dc\uc758 \uc12c\uc720\uc544\uc138\ud3ec\ub85c\uc758 \ubcc0\ud654\ub97c \ud655\uc778\ud588\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uc12c\uc720\ud654 \ubc0f \uc870\uc9c1 \uc7ac\uad6c\uc131 \uad00\ub828 \uc2e0\ud638\ub4e4\uc774 \uc99d\uac00\ud588\uc73c\uba70, \ud3d0 \uc12c\uc720\ud654 \uc870\uc9c1\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ubc18\uc751\uacfc \uc720\uc0ac\ud55c \ud2b9\uc9d5\uc774 \uad00\ucc30\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ud2b9\ud788 \uc774\ub7ec\ud55c \uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd\uc774 \ub2e8\uc21c\ud788 \uc885\uc591 \ubc1c\uc0dd \ud6c4\uc758 \ubd80\uc0b0\ubb3c\uc774 \uc544\ub2c8\ub77c, \uc554 \uc131\uc7a5\uc744 \ub3d5\ub294 \ud658\uacbd\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4. \ubcc0\ud615\ub41c \uc12c\uc720\uc544\uc138\ud3ec\ub294 \uc774\ud6c4 \ub300\uc2dd\uc138\ud3ec\ub97c \uc720\ub3c4\ud558\uace0, \uc5fc\uc99d\uc131 \ub300\uc2dd\uc138\ud3ec \ubc0f \uc885\uc591 \uad00\ub828 \ub300\uc2dd\uc138\ud3ec(tumor-associated macrophage, TAM) \ud615\uc131\uacfc \uc5f0\uacb0\ub418\uba70 \uc5fc\uc99d\uc131 \ubbf8\uc138\ud658\uacbd\uc744 \uac15\ud654\ud55c\ub2e4. \uacb0\uad6d \uc0c1\ud53c\uc138\ud3ec, \uc12c\uc720\uc544\uc138\ud3ec, \ub300\uc2dd\uc138\ud3ec \uc0ac\uc774\uc758 \uc0c1\ud638\uc791\uc6a9\uc774 \u2018\uc790\uae30 \uac15\ud654\uc801 \ud68c\ub85c\u2019\ub97c \ub9cc\ub4e4\uba70 \ubbf8\uc138\ud658\uacbd\uc774 \uc9c0\uc18d\uc801\uc73c\ub85c \uc99d\ud3ed\ub418\ub294 \uad6c\uc870\ub97c \ub9cc\ub4e0\ub2e4.<\/p>\n

 <\/p>\n

KRAS <\/b>\ubcc0\uc774 \uc138\ud3ec\ub294 \uc8fc\ubcc0 \uc870\uc9c1\uc744 \uc5b4\ub5bb\uac8c \ubc14\uafb8\ub294\uac00<\/b><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 KRAS \ubcc0\uc774\ub97c \uac00\uc9c4 AT2 \uc138\ud3ec\uac00 \ub2e8\uc21c\ud788 \uc2a4\uc2a4\ub85c \uc99d\uc2dd\ud558\ub294 \ub370\uc5d0 \uadf8\uce58\uc9c0 \uc54a\uace0, \uc8fc\ubcc0 \uc870\uc9c1\uc744 \uc7ac\uad6c\uc131\ud55c\ub2e4\ub294 \uc810\uc5d0 \uc8fc\ubaa9\ud588\ub2e4. \uc774\ub7ec\ud55c \ubcc0\ud654\uc758 \uc2dc\uc791\uc810\uc740 KRAS \ubcc0\uc774 \uc0c1\ud53c\uc138\ud3ec\uc5d0\uc11c \ubd84\ube44\ub418\ub294 AREG(amphiregulin, \uc554\ud53c\ub808\uade4\ub9b0)\uc774\ub2e4. AREG\ub294 \uc0c1\ud53c\uc138\ud3ec \uc131\uc7a5\uc778\uc790 \uc218\uc6a9\uccb4(epidermal growth factor receptor, EGFR)********* \uc2e0\ud638\ub97c \ud65c\uc131\ud654\ud558\uace0, \uc870\uc9c1 \uc7ac\uc0dd\uacfc \uc138\ud3ec \uc131\uc7a5\uc5d0 \uad00\uc5ec\ud558\ub294 \uc2e0\ud638 \ubb3c\uc9c8\uc774\ub2e4. KRAS \ubcc0\uc774\ub97c \uac00\uc9c4 AT2 \uc138\ud3ec\uac00 AREG\ub97c \ubd84\ube44\ud558\uace0, \uc774\uac83\uc774 \uc8fc\ubcc0 \uc12c\uc720\uc544\uc138\ud3ec\uc758 EGFR \uc2e0\ud638\ub97c \ud65c\uc131\ud654\ud55c\ub2e4. \uc774\ud6c4 \uc12c\uc720\uc544\uc138\ud3ec\ub294 \uc815\uc0c1 \uc0c1\ud0dc\uc5d0\uc11c \uc12c\uc720\ud654\uc131 \uc0c1\ud0dc\ub85c \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d\ub41c\ub2e4. \uc774\ub807\uac8c \ubcc0\ud654\ud55c \uc12c\uc720\uc544\uc138\ud3ec\ub294 \uc138\ud3ec\uc678\uae30\uc9c8 \uc7ac\uad6c\uc131\uacfc \uc5fc\uc99d\uc131 \uc2e0\ud638 \uc804\ub2ec\uc744 \ucd09\uc9c4\ud574 \uc870\uc9c1 \uad6c\uc870\ub97c \ubcc0\ud654\uc2dc\ud0a8\ub2e4. \uc774\ub7ec\ud55c \uacfc\uc815\uc740 \uc77c\ud68c\uc131\uc774 \uc544\ub2c8\ub77c, \uc8fc\ubcc0 \ubbf8\uc138\ud658\uacbd\uc744 \uacc4\uc18d\ud574\uc11c \uc99d\ud3ed\uc2dc\ud0a4\ub294 \ubc29\ud5a5\uc73c\ub85c \uc791\ub3d9\ud55c\ub2e4. \uc6b0\uc120 KRAS \ubcc0\uc774\ub97c \uac00\uc9c4 \uc0c1\ud53c\uc138\ud3ec \uc790\uccb4\uac00 \uba3c\uc800 \ubcc0\ud654\ud558\uace0, \uc774\ud6c4 AREG\uac00 \ubd84\ube44\ub418\uba70 \uc12c\uc720\uc544\uc138\ud3ec\uac00 \uc12c\uc720\ud654\uc131 \uc0c1\ud0dc\ub85c \ubc14\ub00c\uac8c \ub41c\ub2e4. \uc774\uc5b4\uc11c \ubcc0\ud654\ud55c \uc12c\uc720\uc544\uc138\ud3ec\ub294 \ub300\uc2dd\uc138\ud3ec\ub97c \ubaa8\uc9d1\ud574 \uc5fc\uc99d\uc131 \ubbf8\uc138\ud658\uacbd\uc744 \ud615\uc131\ud558\uace0, \uc774 \ud658\uacbd\uc740 \ub2e4\uc2dc \uc0c1\ud53c\uc138\ud3ec\uc758 \ubcc0\ud654\ub97c \uc9c0\uc18d\uc2dc\ud0a4\ub294 \ubc29\ud5a5\uc73c\ub85c \uc791\uc6a9\ud55c\ub2e4. \uc774\ub7ec\ud55c \uacfc\uc815\uc774 \ubc18\ubcf5\ub418\uba70 \uc5fc\uc99d\uc131 \ud658\uacbd\uc774 \uc9c0\uc18d\uc801\uc73c\ub85c \uac15\ud654\ub41c\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 AREG-EGFR \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ucc28\ub2e8\ud558\uba74, \uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd \ud615\uc131\uc774 \uc5b5\uc81c\ub418\uace0, \ucd08\uae30 \ud3d0\uc554 \ubc1c\uc0dd \ub610\ud55c \ud06c\uac8c \uac10\uc18c\ud568\uc744 \ud655\uc778\ud588\ub2e4. \uc774\ub97c \ud1b5\ud574 \ud3d0\uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc785\uc99d\ud588\ub2e4.<\/p>\n

 <\/p>\n

\ucd08\uae30 \ud3d0\uc554 \uc870\uc9c1\uc744 \uc815\ubc00 \ucd94\uc801\ud558\ub2e4<\/b><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc5b4\ub5a4 \uc138\ud3ec\ub4e4\uc774 \uc5b4\ub5bb\uac8c \ubcc0\ud558\ub294\uc9c0 \ubd84\uc11d\ud558\uae30 \uc704\ud574 \ub2e8\uc77c\uc138\ud3ec RNA \uc2dc\ud000\uc2f1(single cell RNA sequencing)\uacfc \uba74\uc5ed \ud615\uad11 \ubd84\uc11d\ubc95(immunofluorescence analysis)\uc744 \uc0ac\uc6a9\ud588\ub2e4. \uae30\uc874\uc758 \ubc8c\ud06c(bulk) RNA \ubd84\uc11d\ubc95\uc740 \uc870\uc9c1 \uc804\uccb4\uc758 \ud3c9\uade0\uc801\uc778 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \ubcf4\uae30 \ub54c\ubb38\uc5d0 \uc138\ud3ec\ub4e4 \uc0ac\uc774\uc5d0 \uc5b4\ub5a4 \uc0c1\ud638\uc791\uc6a9\uc774 \uc77c\uc5b4\ub098\ub294\uc9c0, \uc5b4\ub5a4 \uc138\ud3ec\uac00 \ubcc0\ud654\ud558\ub294\uc9c0 \ub4f1 \ub2e8\uc77c\uc138\ud3ec\uc5d0 \ub300\ud55c \uc815\ud655\ud55c \uc815\ubcf4\ub97c \uc5bb\uae30 \uc5b4\ub835\ub2e4\ub294 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \ub2e8\uc77c\uc138\ud3ec RNA \uc2dc\ud000\uc2f1\uc740 \uc138\ud3ec \ud558\ub098\ud558\ub098\uc758 \uc720\uc804\uc790 \ubc1c\ud604 \ubcc0\ud654\ub97c \ubd84\uc11d\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4. \uc774\ub97c \ud1b5\ud574 \ucd08\uae30 \ud3d0\uc554 \uc870\uc9c1\uc5d0\uc11c \uc5b4\ub5a4 \uc138\ud3ec \uc0c1\ud0dc\uac00 \ud615\uc131\ub418\ub294\uc9c0 \uc815\ubc00\ud558\uac8c \uad00\ucc30\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 KRAS \ubcc0\uc774\ub97c \uc720\ub3c4\ud55c \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \ud65c\uc6a9\ud574 \ud3d0\uc554\uc774 \uc2dc\uc791\ub418\ub294 \ucd08\uae30\uc758 \uc870\uc9c1 \ubcc0\ud654\ub97c \uc2dc\uac04\ub300\ubcc4\ub85c \ucd94\uc801\ud588\ub2e4. \uadf8 \uacb0\uacfc, \uc885\uc591 \ud615\uc131 \uc804\ubd80\ud130 \uc8fc\ubcc0 \uc12c\uc720\uc544\uc138\ud3ec\uc640 \ub300\uc2dd\uc138\ud3ec\uac00 \ubcc0\ud654\ud558\uba70 \uc885\uc591 \uce5c\ud654\uc801 \ubbf8\uc138\ud658\uacbd\uc774 \uc870\uc131\ub418\uace0 \uc788\uc74c\uc744 \ud655\uc778\ud588\ub2e4. \ub610\ud55c \uc778\uac04 \ud3d0\uc120\uc554 \uc870\uc9c1\uacfc \uc815\uc0c1 \ud3d0 \uc870\uc9c1\uc744 \ube44\uad50 \ubd84\uc11d\ud574 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \uad00\ucc30\ub41c \uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd \ud615\uc131\uc774 \uc2e4\uc81c \uc778\uac04 \ud3d0 \uc870\uc9c1\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud558\uac8c \ub098\ud0c0\ub098\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4. \uc774\ud6c4 \uc778\uac04 AT2 \uc138\ud3ec \uae30\ubc18\uc758 \uc0bc\ucc28\uc6d0 \uc778\uacf5 \uc7a5\uae30\uc778 \uc624\uac00\ub178\uc774\ub4dc(organoid) \ubaa8\ub378\uc744 \ud1b5\ud574 KRAS \ubcc0\uc774 \uc138\ud3ec\uac00 \uc8fc\ubcc0 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \uc7ac\uad6c\uc131\ud558\uba70 \uc12c\uc720\ud654\uc131 \ubbf8\uc138\ud658\uacbd\uc744 \ud615\uc131\ud558\ub294 \uacfc\uc815\uc744 \uac80\uc99d\ud588\ub2e4.<\/p>\n

 <\/p>\n

\ud3d0\uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc5f4\ub2e4<\/b><\/p>\n

\uc774\uc804\uc758 \uc554 \uce58\ub8cc \ub300\ubd80\ubd84\uc740 \uc885\uc591 \uc81c\uac70\uc5d0 \uc9d1\uc911\ud588\uc73c\ub098, \ucd5c\uadfc\uc5d0\ub294 \ucd08\uae30 \ubc1c\uacac\uc774 \uc911\uc694\ud574\uc9c0\uace0 \uc788\ub2e4. \uc554\uc744 \ucd5c\ub300\ud55c \ube68\ub9ac \ubc1c\uacac\ud560\uc218\ub85d \uc0dd\uc874\uc728\uc740 \ub192\uc544\uc9c4\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \ucd08\uae30 \ud3d0\uc554 \uacfc\uc815\uc5d0\uc11c AREG\uac00 \ub9e4\uc6b0 \ub192\uac8c \ub098\uc628 \uc810\uc744 \ud65c\uc6a9\ud574, \ucd08\uae30 \ubc1c\uacac\uc758 \ub9c8\ucee4\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc5f4\uc5c8\ub2e4. \ub354\ubd88\uc5b4 \uce58\ub8cc \ubc29\uc2dd\uc758 \ubc1c\uc804 \uac00\ub2a5\uc131\ub3c4 \uc5f4\uc5c8\ub2e4. \ud3d0\uc554\uc758 \ubcc0\uc774\uc5d0\ub294 \ud06c\uac8c KRAS\uc640 EGFR \ub450 \uac00\uc9c0 \uc885\ub958\uac00 \uc788\ub2e4. \uc784\uc0c1\uc801\uc73c\ub85c EGFR \ubcc0\uc774\uc5d0\ub294 EGFR \ud45c\uc801 \uce58\ub8cc\ub97c, KRAS \ubcc0\uc774\uc5d0\ub294 KRAS \ud45c\uc801 \uce58\ub8cc\ub97c \uc9c4\ud589\ud574 \uc654\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 KRAS \ubcc0\uc774 \uc554\uc138\ud3ec\uac00 \uc8fc\ubcc0 \ud658\uacbd\uc744 \ubc14\uafc0 \ub54c EGFR \uc2e0\ud638(AREG)\ub97c \uc774\uc6a9\ud55c\ub2e4\ub294 \uc810\uc744 \ubc1d\ud600\ub0c8\ub2e4. \ucd5c \uad50\uc218\ub294 \u201cKRAS \ubcc0\uc774 \ud3d0\uc554\uc774\ub77c \ud560\uc9c0\ub77c\ub3c4 \ucd08\uae30\uc5d0 EGFR \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ucc28\ub2e8\ud558\uba74 \uc554\uc138\ud3ec\uac00 \uc8fc\ubcc0 \ubbf8\uc138\ud658\uacbd\uc744 \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d\ud558\ub294 \uacfc\uc815\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc5b4, \ud3d0\uc554 \ubc1c\uc0dd\uc744 \uc6d0\ucc9c \ucc28\ub2e8\ud558\ub294 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc811\uadfc\uc774 \uac00\ub2a5\ud560 \uac83\u201d\uc774\ub77c\uace0 \uc804\ud588\ub2e4.<\/p>\n

 <\/p>\n

\uc5f0\uad6c\ud300\uc740 \uae30\ubcf8\uc801\uc73c\ub85c \ud3d0\uc640 \uba74\uc5ed\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc9c0\uc18d\ud558\uace0 \uc788\ub2e4. \ud3d0\uc5d0 \uc190\uc0c1\uc774 \uc0dd\uacbc\uc744 \ub54c, \uc904\uae30\uc138\ud3ec\ub4e4\uc758 \ubcf5\uad6c \uacfc\uc815\uacfc \uadf8 \uacfc\uc815\uc5d0\uc11c\uc758 \uc904\uae30\uc138\ud3ec\uc640 \ubbf8\uc138\ud658\uacbd\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \uc5f0\uad6c\ud55c\ub2e4. \uc870\uc9c1\uc5d0\uc11c \ubc1c\uc0dd\ud55c \uc190\uc0c1\uc744 \ub1cc\uc5d0\uc11c \uc5b4\ub5bb\uac8c \uc778\uc2dd\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub3c4 \uc8fc\uc694 \ubaa9\ud45c\ub2e4. \ub610\ud55c, \uc870\uc9c1 \uc190\uc0c1\uc774\ub098 \ucd08\uae30 \uc5fc\uc99d\uc758 \uacbd\ud5d8\uc774 \uc774\ud6c4\uc5d0\ub3c4 \uc138\ud3ec\uc640 \ubbf8\uc138\ud658\uacbd\uc5d0 \u2018\uae30\uc5b5(memory)\u2019 \ud615\ud0dc\ub85c \ub0a8\uc544, \ubbf8\ub798\uc758 \uc190\uc0c1 \ubc18\uc751 \ub610\ub294 \uc9c8\ubcd1 \ubc1c\uc0dd \uacfc\uc815\uc5d0 \uc601\ud5a5\uc744 \uc8fc\ub294 \uc6d0\ub9ac\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uad81\uadf9\uc801\uc778 \ubaa9\ud45c\ub85c \uaf3d\uc558\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

* \uc138\ud3ec \ud45c\uba74\uc758 \uc218\uc6a9\uccb4 \ub2e8\ubc31\uc9c8 \uc0dd\uc131 \uc720\uc804\uc790\ub85c, \ub3cc\uc5f0\ubcc0\uc774 \ubc1c\uc0dd \uc2dc \uc138\ud3ec\uac00 \ubb34\ud55c\ud788 \ubd84\uc5f4
\n**\uc138\ud3ec \uc131\uc7a5\uacfc \ubd84\uc5f4 \uc2e0\ud638\ub97c \uc804\ub2ec\ud558\ub294 \uc138\ud3ec \ub0b4 \ubd84\uc790 \uc2a4\uc704\uce58\ub85c, \ub3cc\uc5f0\ubcc0\uc774 \ubc1c\uc0dd \uc2dc \uc138\ud3ec\uc758 \ubb34\uc81c\ud55c \uc790\uc728 \uc99d\uc2dd \ubc0f \uc554\ud654\ub97c \uc720\ubc1c
\n***\ud608\uad00\uc744 \uad6c\uc131\ud558\uace0 \uc720\uc9c0\ud558\ub294 \uc138\ud3ec
\n****\ub3d9\ubb3c \uc870\uc9c1\uc758 \uad6c\uc870\uc801 \ud2c0(\uae30\uc9c8)\uc744 \uc0dd\uc131\ud558\uba70 \uc0c1\ucc98 \uce58\uc720\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uc138\ud3ec
\n*****\uc778\uccb4 \uba74\uc5ed\uc138\ud3ec\uc758 \uc77c\uc885, \uccb4\ub0b4\uc5d0 \uce68\uc785\ud55c \ubcd1\uc6d0\uade0\uc774\ub098 \uc720\ud574 \ubb3c\uc9c8 \ub4f1\uc744 \ucc98\ub9ac\ud558\ub294 \uc138\ud3ec
\n******\uc138\ud3ec \ubc16 \uacf5\uac04\uc744 \ucc44\uc6b0\uace0 \uc788\ub294 \uad6c\uc870\ubb3c \ubc0f \ubd84\uc790\ub4e4\uc758 \uc9d1\ud569
\n*******\uc544\uc9c1 \ubd84\ud654\ud558\uc9c0 \uc54a\uc544 \ub2e4\ub978 \uc138\ud3ec\ub85c \ubd84\ud654 \uac00\ub2a5\ud55c \uc138\ud3ec
\n********\ud3d0\ud3ec\ub97c \uad6c\uc131\ud558\ub294 \uc0c1\ud53c\uc138\ud3ec
\n*********\uc0c1\ud53c\uc138\ud3ec \ud45c\uba74\uc5d0 \uc704\uce58\ud558\uc5ec \uc138\ud3ec\uc758 \uc131\uc7a5, \ubd84\ud654 \ubc0f \uc0dd\uc874\uc744 \uc870\uc808\ud558\ub294 \uc138\ud3ec\ub9c9 \ub2e8\ubc31\uc9c8<\/p>\n","protected":false},"excerpt":{"rendered":"

GIST \uc0dd\uba85\uacfc\ud559\uacfc \ucd5c\uc9c4\uc6b1 \uad50\uc218 \uc5f0\uad6c\ud300\uc774 \ud3d0\uc554\uc758 \u2018\uc554\uc774 \uc790\ub77c\uae30 \uc26c\uc6b4 \ud658\uacbd\u2019 \ud615\uc131 \uacfc\uc815\uc744 \uaddc\uba85\ud588\ub2e4. \ud3d0\uc554\uc774 \ubcf8\uaca9\uc801\uc778 \uc885\uc591\uc73c\ub85c \uc131\uc7a5\ud558\uae30 \uc774\uc804\ubd80\ud130 \uc8fc\ubcc0 \uc870\uc9c1\uc774 \uc554 \uc131\uc7a5\uc5d0 \uc720\ub9ac\ud55c \ud658\uacbd\uc73c\ub85c \ubcc0\ud654\ud558\ub294 \uacfc\uc815\uc744 \ubc1d\ud78c \uac83\uc774\ub2e4. \uc774\ubc88 \uc5f0\uad6c \uc131\uacfc\ub294 \uc554 \uc608\ubc29\uc5d0 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud574 2026\ub144 4\uc6d4 22\uc77c \uad6d\uc81c \ud559\uc220\uc9c0 <\ub124\uc774\ucc98(Nature)>\uc5d0 \uac8c\uc7ac\ub410\ub2e4.   \uc554\uc740 \ud63c\uc790 \uc790\ub77c\uc9c0 \uc54a\ub294\ub2e4 \uc554\uc740 \uc6b0\ub9ac \ubab8\uc758 \uc138\ud3ec\uac00 \uc720\uc804\uc790 \ubcc0\uc774\ub85c \uc778\ud574 […]<\/p>\n","protected":false},"author":38,"featured_media":7466,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_post_was_ever_published":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[32,248,81],"tags":[],"coauthors":[324],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/gistnews.co.kr\/wp-content\/uploads\/2026\/07\/ED9599EC88A0_EC82ACECA784_EC8898ECA095.png?fit=1957%2C1036&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pdL9j0-1Wp","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7465"}],"collection":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7465"}],"version-history":[{"count":1,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7465\/revisions"}],"predecessor-version":[{"id":7467,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/7465\/revisions\/7467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=\/wp\/v2\/media\/7466"}],"wp:attachment":[{"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7465"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/gistnews.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcoauthors&post=7465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}